运动干预药物依赖的神经生物学机制研究进展

发布时间：2019-01-27 13:29

【摘要】：流行病学研究证实,有规律的有氧运动能降低药物滥用的可能性。基础和临床研究显示,运动可作为药物依赖的一种潜在的干预手段,在成瘾依赖的各个阶段产生有益和持久的保护作用。运动的这种保护作用与其调节药物依赖相关的神经适应性改变有关。运动可调节各种神经递质系统以及细胞内信号传递,增加脑源性神经营养因子水平,促进神经再生和胶质细胞再生和调控表观遗传学变化等提升大脑对成瘾物质损害的抵抗力,降低大脑对药物的渴求感,预防复吸。此外,运动的强度、时间和类型不同也会产生不同的神经生物学机制。本文着重从运动干预药物依赖的神经生物学机制方面综述了以运动为基础的单独或辅助其他治疗手段干预药物成瘾。
[Abstract]:Epidemiological studies have shown that regular aerobic exercise reduces the likelihood of drug abuse. Basic and clinical studies have shown that exercise can act as a potential intervention in drug dependence and has beneficial and lasting protective effects at all stages of addiction dependence. This protective effect of exercise is related to its regulation of neuroadaptive changes associated with drug dependence. Exercise can regulate various neurotransmitter systems and intracellular signal transduction, increase the level of brain-derived neurotrophic factor, promote nerve regeneration and glial cell regeneration, and regulate epigenetic changes to enhance the brain resistance to the damage of addictive substances. Reduce brain craving for drugs and prevent relapse. In addition, different intensity, time and type of exercise also produce different neurobiological mechanisms. This paper reviews the neurobiological mechanism of exercise intervention in drug dependence.
【作者单位】：宁波大学医学院;宁波戒毒研究中心;
【基金】：“十二五”支撑项目(2012BAI01B07) 国家自然科学基金(U1132602)~~
【分类号】：R96

【共引文献】