喹硫平致库欣综合征患者血清皮质醇水平下降的临床药效学研究

发布时间：2019-01-30 12:13

【摘要】：目的评价喹硫平降低库欣综合征患者血清皮质醇水平的有效性。方法通过一例库欣综合征患者应用喹硫平后血清皮质醇和促肾上腺皮质激素(ACTH)水平的变化,并对喹硫平致皮质醇水平降低的相关文献进行检索分析,分析喹硫平降低皮质醇水平的机制。结果 1例44岁男性库欣综合征患者睡前服用喹硫平0.05 g后血清皮质醇水平(8am)由34.73μg·d L~(-1) 降至5.68μg·d L~(-1) ,并于喹硫平停药1 d后回升至22.96μg·d L~(-1) ;ACTH水平由用药前99.2 pg·m L~(-1) 降至74.3 pg·m L~(-1) 。查阅文献喹硫平致皮质醇水平降低的有7项研究,均以精神病患者或健康受试者为研究对象,血清皮质醇水平降幅在6.9~2.7μg·d L~(-1) 。结论喹硫平可以降低精神病患者与库欣综合征患者以及健康人群的皮质醇水平。笔者对pumed、EMbase等数据库检索,均未见相关报道,本例是笔者检索到的首例喹硫平降低库欣综合征患者的血清皮质醇水平的病例报道。
[Abstract]:Objective to evaluate the efficacy of quetiapine in reducing serum cortisol levels in patients with Cushing's syndrome. Methods the changes of serum cortisol and adrenocorticotropic hormone (ACTH) levels in a patient with Cushing syndrome were analyzed. To analyze the mechanism of quetiapine decreasing cortisol level. Results the serum cortisol level (8am) decreased from 34.73 渭 g d L ~ (-1) to 5.68 渭 g L ~ (-1) in a 44-year-old male with Cushing's syndrome. The level of quintiapine was increased to 22.96 渭 g / d L ~ (-1) after one day. The level of ACTH decreased from 99.2 pg mL ~ (-1) to 74.3 pg mL ~ (-1). There were 7 studies in which the cortisol level was decreased by quintiapine in 7 subjects. The serum cortisol level was decreased by 6.9U 2.7 渭 g / d L ~ (-1) in patients with mental illness or in healthy subjects. Conclusion Quintiapine can reduce cortisol levels in patients with psychosis, Cushing's syndrome and healthy people. There were no related reports on pumed,EMbase and other databases. This case is the first case that quetiapine reduces serum cortisol level in patients with Cushing's syndrome.
【作者单位】：中国医学科学院北京协和医学院北京协和医院药剂科;河南科技大学第一附属医院药学部;中国医学科学院北京协和医学院北京协和医院内分泌科卫生计生委内分泌重点实验室;山西省阳泉市第一人民医院内分泌科;中国医学科学院北京协和医学院北京协和医院心理医学科;
【分类号】：R969

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