肼苯哒嗪联合硝酸异山梨醇酯对心力衰竭大鼠的影响

发布时间：2019-02-09 20:34

【摘要】：目的探讨肼苯哒嗪联合硝酸异山梨醇酯对心力衰竭模型大鼠的影响。方法 40只成年健康雄性大鼠,随机选取10只为正常组,其余进行心力衰竭模型复制,将模型大鼠按数字表法随机分为3组,模型组、实验组、对照组,每组10只。模型组与正常组每日灌胃生理盐水3 m L,对照组予以贝那普利(90mg·kg-1)+比索洛尔氢氯噻嗪片(45 mg·kg-1)灌胃3 m L,实验组予以硝酸异山梨醇酯(800 mg·kg-1)+肼苯哒嗪(225 mg·kg-1),每天灌胃1次3 m L。实验结束后,比较各组大鼠心功能、半胱氨酸(Cys)、同型半胱氨酸(Hcy)、脑钠肽(BNP)、肿瘤坏死因子α(TNF-α)水平及心肌组织形态。结果与模型组比较,实验组与对照组大鼠的BNP、TNF-α水平水平较低,Cys及Hcy水平较高,心功能恢复较好;与对照组比较,实验组大鼠BNP、TNF-α水平水平较低,Cys及Hcy水平较高,心功能恢复较好(均P0.05)。结论肼苯哒嗪联合硝酸异山梨醇酯能够明显缓解心力衰竭症状对机体的影响,降低血脑钠肽及改善左心室功能、抑制肿瘤坏死因子及同型半胱氨酸的表达。
[Abstract]:Objective to investigate the effect of hydrapyridazine combined with isosorbide nitrate on heart failure rats. Methods Forty adult healthy male rats were randomly selected as normal group and the rest were randomly divided into 3 groups: model group, experimental group, control group, each group with 10 rats in each group. The model group and the normal group were intragastrically perfused with normal saline 3 mL daily, while the control group were treated with 90mg kg-1 Bisoprolol hydrochlorothiazide tablets (45 mg kg-1). The experimental group was given isosorbide nitrate (800 mg kg-1) hydrazepyridazine (225 mg kg-1) once a day for 3 mL. At the end of the experiment, cardiac function, cysteine (Cys), homocysteine (Hcy), brain natriuretic peptide (BNP), tumor necrosis factor 伪 (TNF- 伪) and myocardial histomorphology were compared. Results compared with the model group, the levels of BNP,TNF- 伪, Cys and Hcy in the experimental group and the control group were lower, and the cardiac function recovered better. Compared with the control group, the level of BNP,TNF- 伪 was lower, the levels of Cys and Hcy were higher and the cardiac function recovered better in the experimental group (P0.05). Conclusion hydrapyridazine combined with isosorbide nitrate can significantly alleviate the effects of heart failure on body, decrease blood brain natriuretic peptide and improve left ventricular function, and inhibit the expression of tumor necrosis factor and homocysteine.
【作者单位】：唐山市工人医院检验科;唐山市工人医院心外一科;唐山市工人医院心内科;
【基金】：2013年唐山市科学技术研究与发展指导计划基金资助项目(13130269b)
【分类号】：R965

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