绿色分析技术及其在药物分析中的应用研究进展

发布时间：2019-02-23 18:16

【摘要】：用于药物分析的色谱和光谱等分析法需要大量有机溶剂,并产生大量挥发性废弃物,对环境有害。减少或消除有机溶剂消耗而又无损分析效果的绿色分析技术日益受到重视。本文就色谱、光谱及其它分析技术的绿色化策略的最新进展进行了综述。重点从降低溶剂消耗和使用绿色替代溶剂两方面来阐述绿色液相色谱技术的发展,包括绿色样品制备技术、快速液相色谱、液相系统的小型化及乙醇、纯水等替代溶剂的使用。并简单介绍气相色谱法、生物分析技术、光谱法及其他分析技术的绿色化应用进展。同时,本文还就绿色分析技术在药物分析中的发展趋势进行了讨论和展望。
[Abstract]:Chromatographic and spectroscopic analysis for drug analysis requires a large number of organic solvents and produces a large amount of volatile waste, which is harmful to the environment. Green analytical techniques that reduce or eliminate organic solvent consumption without loss of analytical effect have been paid more and more attention. In this paper, the recent advances in greening strategies of chromatography, spectrum and other analytical techniques are reviewed. The development of green liquid chromatography technology, including green sample preparation technology, rapid liquid chromatography, miniaturization of liquid system and the use of ethanol and pure water, is described in detail from the aspects of reducing solvent consumption and using green alternative solvents, such as green sample preparation technology, rapid liquid chromatography, liquid system miniaturization and the use of ethanol and pure water. The green applications of gas chromatography, biological analysis, spectral analysis and other analytical techniques are briefly introduced. At the same time, the development trend of green analysis technology in drug analysis is discussed and prospected.
【作者单位】：扬子江药业集团药物研究院;江苏省食品药品检验所;中国药科大学;
【分类号】：R917

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