不同孔径介孔二氧化硅纳米粒的制备及其用于固化西罗莫司自微乳

发布时间：2019-03-07 08:28

【摘要】：研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。
[Abstract]:Mesoporous silica nanoparticles with different pore sizes and sirolimus self-microemulsion were prepared. The mesoporous silica nanoparticles were prepared by scanning electron microscopy (SEM), transmission electron microscopy (TEM), small angle X-ray diffraction (XRD) and nitrogen adsorption-desorption. It was found that the mesoporous silica nanoparticles were ordered nanoporous structures with pore sizes of 6.3, 8.1 and 10.8 nm, respectively. The size of sirolimus self-microemulsion was 20. 6 卤1. 3 nm. measured by particle size analyzer. Sirolimus-loaded self-microemulsion mesoporous silica nanoparticles were prepared by agitation method. It was found that when the mass ratio of sirolimus self-microemulsion to mesoporous silica nanoparticles was 2: 1, the drug loading was about 0.83%, and the flowability of solid powder was good. Differential scanning calorimetry (DSC) shows that sirolimus exists as amorphous or amorphous in the carrier material and has good re-dispersibility. The pore size had no significant effect on the end point of self-microemulsion mesoporous silica nanoparticles containing sirolimus in 250ml water for 2 h, but had a greater effect on the initial 40 min release results. In summary, mesoporous silica nanoparticles are expected to become a new self-microemulsion adsorbent.
【作者单位】：南京军区福州总医院;福建医科大学药学院;厦门大学医学院;
【基金】：福建省科技计划重点资助项目(2013Y0074)
【分类号】：R943

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