二甲双胍抗肿瘤机制研究进展
发布时间：2019-03-08 13:50
【摘要】：正二甲双胍自1957年首次应用于临床以来,因治疗糖尿病疗效显著,副作用小,价格低廉等优点,目前已被确定为2型糖尿病(type 2 diabetes,T2DM)治疗的一线药。值得注意的是,自从2005年首次发现二甲双胍可以降低糖尿病患者恶性肿瘤的发生率后,越来越多的研究者关注其抗肿瘤作用,本文就其抗癌机制做一综述。1二甲双胍与肿瘤目前,越来越多的流行病学研究发现,二甲双胍可以降低
[Abstract]:Since it was first used in clinical practice in 1957, metformin has been identified as a first-line drug for type 2 diabetes mellitus (type-2 diabetes,T2DM) because of its obvious curative effect, small side effect and low price. It is worth noting that, since it was first discovered in 2005 that metformin can reduce the incidence of malignant tumors in diabetic patients, more and more researchers have focused on its antitumor effects. 1 at present, more and more epidemiological studies on metformin and tumor have found that metformin can reduce the incidence of cancer.
【作者单位】： 广州医科大学附属肿瘤医院肿瘤研究所;广州医科大学附属第五医院;
【基金】：国家自然科学基金资助项目(编号:81402011) 珠江科技新星项目(编号:2012J2200032) 广东省科技计划项目(编号:2013B021800178) 广东省教育厅青年创新人才和广东省优秀青年人才类项目
【分类号】：R96
[Abstract]:Since it was first used in clinical practice in 1957, metformin has been identified as a first-line drug for type 2 diabetes mellitus (type-2 diabetes,T2DM) because of its obvious curative effect, small side effect and low price. It is worth noting that, since it was first discovered in 2005 that metformin can reduce the incidence of malignant tumors in diabetic patients, more and more researchers have focused on its antitumor effects. 1 at present, more and more epidemiological studies on metformin and tumor have found that metformin can reduce the incidence of cancer.
【作者单位】： 广州医科大学附属肿瘤医院肿瘤研究所;广州医科大学附属第五医院;
【基金】：国家自然科学基金资助项目(编号:81402011) 珠江科技新星项目(编号:2012J2200032) 广东省科技计划项目(编号:2013B021800178) 广东省教育厅青年创新人才和广东省优秀青年人才类项目
【分类号】：R96
【参考文献】
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