生物活性玻璃混悬型软膏剂的制备

发布时间：2019-03-11 18:12

【摘要】：目的制备具有高比表面积的介孔生物活性玻璃的软膏剂。方法采用有机模板法制备介孔生物活性玻璃,以模拟生理体液(simulated body fluid,SBF)验证其矿化性能,以扫描电子显微镜(scanning electron microscope,SEM)、红外光谱(frontier infrared spectroscopy,FT-IR)、比表面积孔径分析仪对矿化前后的生物活性玻璃进行表征。以十八醇-丙二醇(fatty alcohol-propylene glycol,FAPG)为基质制备软膏剂,对软膏的p H值、黏度以及对高温、高湿的稳定性进行测定。结果制得的介孔生物活性玻璃粒径为6μm,大小均一,表面具有孔径为6 nm的介孔孔道结构,比表面积为768.5 m2·g-1,在SBF溶液中表面可矿化形成碳酸羟基磷灰石层。制得的软膏剂p H值为5.21,黏度为9~69 Pa·s,在高温或高湿环境放置10 d后,软膏的p H值、外观及生物活性玻璃的结构均无明显变化。结论制备的介孔生物活性玻璃同市售的45S5相比比表面积显著提升,对于更快地促进皮肤与软组织的再生具有重要的意义,以其制成的软膏剂p H值适中,黏度适宜,对高温高湿具有较好的稳定性。
[Abstract]:Objective to prepare mesoporous bioactive glass ointment with high specific surface area. Methods mesoporous bioactive glasses were prepared by organic template method. The mineralized properties of mesoporous bioactive glasses were verified by simulating physiological body fluid (simulated body fluid,SBF. Scanning electron microscope (scanning electron microscope,SEM) and infrared spectroscopy (frontier infrared spectroscopy,FT-IR) were used. Specific surface area pore size analyzer was used to characterize bioactive glass before and after mineralization. Using octadecanol-propanediol (fatty alcohol-propylene glycol,FAPG) as substrate, the pH value, viscosity and stability of ointment at high temperature and high humidity were determined. Results the mesoporous bioactive glass has a mesoporous structure of 6 nm and a specific surface area of 768.5 m ~ 2 路g ~ (- 1). The mesoporous bioactive glass can be mineralized to form hydroxyapatite layer in SBF solution. The mesoporous bioactive glass has a homogeneous size and a mesoporous pore structure of 6 渭 m ~ (- 1). The pH value and viscosity of the prepared ointment were 5.21 and 9? 69 Pa 路s, respectively. The pH value, appearance and structure of bioactive glass did not change significantly after 10 days' storage in high temperature or high humidity environment. Conclusion the specific surface area of the mesoporous bioactive glass prepared is significantly higher than that of the 45S5 sold in the market, which is of great significance in promoting the regeneration of skin and soft tissue more quickly. The pH value and viscosity of the ointment made from the mesoporous bioactive glass are moderate and suitable. It has good stability to high temperature and high humidity.
【作者单位】：沈阳药科大学药学院;沈阳药科大学医疗器械学院;
【基金】：国家自然科学基金资助项目(81473165) 辽宁省教育厅科学研究一般项目(L2015515) 沈阳药科大学科研专项基金—青年教师科研启动基金资助项目(51120225)
【分类号】：R943

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