喜树内生真菌Diaporthe sp.XZ-07中的2个新内酯及其抑制肿瘤活性研究
发布时间：2019-03-14 20:19
【摘要】：对1株喜树内生真菌Diaporthe sp.XZ-07的次生代谢产物进行研究。采用RP-18,Sephadex LH-20,硅胶等材料进行色谱柱分离纯化得到2个新化合物,鉴定为5-((E)-1,4,5-trihydroxyhex-2-enyl)furan-2(5H)-one(1)和(5Z)-5-(2,3,4,5-tetrahydroxyhexylidene)furan-2(5H)-one(2)。用MTT法测试化合物活性,结果显示化合物1对Hela有较强抑制活性,化合物2对MCF-7,SH-SY5Y,3LL均有较强抑制活性。
[Abstract]:The secondary metabolites of Diaporthe sp.XZ-07 from an endophytic fungus of Camptotheca acuminata were studied. Two new compounds were isolated and purified on RP-18,Sephadex LH-20, silica gel column. They were identified as 5-(E)-1,4,5-trihydroxyhexa-furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5) furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5Z). 4,5-tetrahydroxyhexylidene furan-2 (5H)-one (2). The activity of compound 1 was tested by MTT method. The results showed that compound 1 had strong inhibitory activity on Hela and compound 2 had strong inhibitory activity on MCF-7,SH-SY5Y,3LL.
【作者单位】： 昆明学院化学科学与技术系;中国科学院昆明植物研究所;
【基金】：国家自然科学基金项目(31260073)
【分类号】：R96;R915
[Abstract]:The secondary metabolites of Diaporthe sp.XZ-07 from an endophytic fungus of Camptotheca acuminata were studied. Two new compounds were isolated and purified on RP-18,Sephadex LH-20, silica gel column. They were identified as 5-(E)-1,4,5-trihydroxyhexa-furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5) furan-2 (5H)-one (1) and (5Z)-5-(2,3,3,5Z). 4,5-tetrahydroxyhexylidene furan-2 (5H)-one (2). The activity of compound 1 was tested by MTT method. The results showed that compound 1 had strong inhibitory activity on Hela and compound 2 had strong inhibitory activity on MCF-7,SH-SY5Y,3LL.
【作者单位】： 昆明学院化学科学与技术系;中国科学院昆明植物研究所;
【基金】：国家自然科学基金项目(31260073)
【分类号】：R96;R915
【相似文献】
相关期刊论文 前10条
1 何颖;谈锋;谢建平;;红豆杉内生真菌产紫杉醇研究进展[J];天然产物研究与开发;2006年03期
2 苗翠苹;余莹;陈有为;王皎;吴少华;;滇牡丹内生真菌的分离及其抑菌活性研究[J];中国药学杂志;2011年10期
3 黄银芳;范志英;章方s，
本文编号：2440336
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2440336.html
最近更新
教材专著
