甘草酸磷脂复合物自乳化制剂处方筛选

发布时间：2019-03-19 13:01

【摘要】：目的对甘草酸磷脂复合物自乳化制剂(self-emulsifying drug delivery system,SEDDS)进行处方筛选及制备。方法用溶解性实验,处方配伍实验和伪三元相图等方法进行甘草酸磷脂复合物SEDDS制备研究,优选乳化剂,油相和助乳化剂;确定处方组分比例,考察处方自乳化效率。结果最佳甘草酸磷脂复合物SEDDS处方为Labrafil 1944 cs∶Cremophor EL35∶Transcutol HP=45∶40∶15,处方载药量为27.3%;该处方能形成具有乳光透明乳液,粒度分布均匀。结论该方法可成功制备甘草酸磷脂复合物自乳化制剂。
[Abstract]:Objective to screen the prescription of glycyrrhizin complex self-emulsifying agent (self-emulsifying drug delivery system,SEDDS) and to prepare it. Methods the preparation of phosphatidyl glycyrrhizinate complex SEDDS was studied by means of solubility test, prescription compatibility test and pseudo-ternary phase diagram, the emulsifier, oil phase and co-emulsifier were optimized, the proportion of prescription components was determined, and the self-emulsifying efficiency of prescription was investigated. Results the optimal formulation of glycyrrhizin phospholipid complex SEDDS was Labrafil 1944 cs:Cremophor EL35:Transcutol HP=45:40:15, containing 27.3% of the drug, and the emulsion transparent emulsion could be formed with uniform particle size distribution. Conclusion the self-emulsifying preparation of glycyrrhizin complex can be successfully prepared by this method.
【作者单位】：杭州市西溪医院药剂科;
【基金】：浙江省中医药管理局重点项目(2009ZA014)
【分类号】：R943

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