含依诺沙星微球的改性明胶膜的制备及体外释药性研究

发布时间：2019-04-12 09:29

【摘要】：目的制备含有依诺沙星微球的改性明胶膜,并研究其体外释药性。方法以乳化交联法制备依诺沙星明胶微球,以微球粒径、载药量、包封率为指标,应用正交试验优选微球的最佳制备工艺后,将载药微球分散到改性明胶膜中,对比普通载药膜测定其在pH 7.4磷酸盐缓冲液中的释放性。结果以最优工艺制备的依诺沙星微球外观圆整,分布均匀,平均粒径为(3.04±0.25)μm,80%微球粒径分布在1~6μm,微球平均载药量为(11.8±1.02)%,平均包封率为(78.24±3.18)%,载药微球膜和普通药膜中依诺沙星累积释放约80%各需96h和8h。结论依诺沙星微球制备工艺稳定可行,载药微球改性明胶膜体外释放缓慢,有望开发为具有长效抗菌效果的创伤性敷料。
[Abstract]:Objective To prepare modified gelatin film containing enoxacin microballoon and to study its drug release in vitro. The method comprises the following steps of: preparing the enoxacin gelatin microspheres by an emulsion crosslinking method, and dispersing the drug-loaded microspheres into the modified gelatin film after the optimal preparation process of the microspheres by using the particle size, the drug loading and the encapsulation rate of the microspheres; The release of the conventional drug-loaded film in the pH 7.4 phosphate buffer was compared. The results showed that the enoxacin microballoon prepared by the optimal process has the advantages of round appearance, uniform distribution, average particle size of (3.04-0.25) & mu; m, particle size distribution of 80% of the microspheres in the range of 1-6 & mu; m, average drug loading of the microspheres (11.8-1.02)%, and average encapsulation rate (78.24-3.18)%, The cumulative release of enoxacin in the drug-loaded microballoon membrane and the common drug membrane is about 80%, which is 96 h and 8 h. Conclusion The preparation process of enoxacin microsphere is stable and feasible. The release of drug-loaded microsphere modified gelatin film in vitro is slow, and it is expected to be developed as a traumatic dressing with long-acting antibacterial effect.
【作者单位】：福建医科大学药学院实验中心;福建医科大学药学院药物化学系;
【基金】：福建省教育厅科技A类项目(JA13148)
【分类号】：R943

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