338例儿童药品不良反应回顾性分析

发布时间：2019-05-19 16:24

【摘要】：目的:分析笔者所在儿童医院药品不良反应(ADR)的发生特点和规律,为减少患儿ADR发生,促进临床安全合理用药提供参考依据。方法:采用回顾性分析法,对笔者所在医院2013-2014年上报的338例ADR病例进行统计分析。结果:338例ADR病例中,新的和严重的病例占28.40%;给药方式以静脉滴注最多达75.70%;引发ADR最多的为抗菌药物达58.88%;ADR病例数量最多的为注射用头孢呋辛钠达11.54%;338例ADR几乎累及了全身系统,其中皮肤及其附件最多达76.33%;严重ADR在联合用药中的比例(22.00%)高于无联合用药中比例(10.07%);按照类型分,最多的为B型高达82.25%;时间关联性以B型最明确,发现时间在给药后2 h内高达87.77%;A型ADR新的和严重的报表所占比例最高达41.82%。结论:本次调研发现静脉给药30 min内ADR发生率较其他给药途径高;严重的ADR更倾向于在给药后数分钟内发生;联合用药可能是严重ADR发生的一个重要危险因素;B型ADR所占比例最高可能与其时间关联性强有关。
[Abstract]:Objective: to analyze the characteristics and regularity of adverse drug reactions (ADR) in children's hospitals, so as to provide reference for reducing the occurrence of ADR and promoting safe and rational use of drugs in clinic. Methods: the retrospective analysis was used to analyze the 33 8 cases of ADR reported in the author's hospital from 2013 to 2014. Results: of the 33 ADR cases, 28.40% were new and severe, 75.70% were given intravenous drip, 58.88% were antibacterial drugs, 58.88% were caused by intravenous drip, and 58.88% were caused by intravenous drip. The largest number of ADR cases was cefuroxime sodium for injection (11.54%). The number of ADR cases almost involved the whole body system, in which the skin and its accessories were up to 76.33%. The proportion of severe ADR in combined drugs (22.00%) was higher than that in non-combined drugs (10.07%), and the highest percentage of type B was 82.25%. The time correlation of type B was the clearest, and the time was 87.77% within 2 hours after administration, and the proportion of new and serious reports of type A ADR was 41.82%. Conclusion: the incidence of ADR within 30 min of intravenous administration is higher than that of other routes of administration, and severe ADR is more likely to occur within a few minutes after administration. Combined administration may be an important risk factor for the occurrence of severe ADR. The highest proportion of B-type ADR may be related to its strong temporal correlation.
【作者单位】：深圳市儿童医院;
【分类号】：R985

【相似文献】