一种新型苯甲酸衍生物类神经氨酸酶抑制剂的合成及体外酶抑制活性
发布时间：2019-05-20 13:55
【摘要】：本研究基于苯甲酸衍生物类神经氨酸酶抑制剂的结构,依据最新报道的构效关系设计了新的先导化合物 L,并合成4个未见文献报道的苯甲酸衍生物类神经氨酸酶抑制剂 ( Ⅰ~Ⅳ )。活性测试选用流感病毒菌株 H_3N_2( California/04)、H_1N_1(California/99) 和 B(Shanghai/02)。结果显示,化合物Ⅰ~Ⅳ均具有良好的神经氨酸酶抑制作用,含环状分支的Ⅱ活性最佳。
[Abstract]:Based on the structure of the neuraminidase inhibitor of the benzoic acid derivatives, the new pilot compound L was designed according to the structure-effect relationship of the most recent reports, and 4 kinds of neuraminidase inhibitors (I-IV), which were not reported in the literature, were synthesized. The activity tests were influenza virus strain H _ 3N _ 2 (California/04), H _ 1N _ 1 (California/99) and B (Shanghai/02). The results showed that the compounds I to IV had good inhibitory effect on neuraminidase, and the 鈪，
本文编号：2481693
[Abstract]:Based on the structure of the neuraminidase inhibitor of the benzoic acid derivatives, the new pilot compound L was designed according to the structure-effect relationship of the most recent reports, and 4 kinds of neuraminidase inhibitors (I-IV), which were not reported in the literature, were synthesized. The activity tests were influenza virus strain H _ 3N _ 2 (California/04), H _ 1N _ 1 (California/99) and B (Shanghai/02). The results showed that the compounds I to IV had good inhibitory effect on neuraminidase, and the 鈪，
本文编号：2481693
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