114例别嘌醇不良反应文献分析

发布时间：2019-05-27 15:28

【摘要】：目的:探讨别嘌醇致不良反应发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网(CNKI)的中国医院知识仓库(CHKD)期刊全文数据库及万方数据库,检索2000 2015年有关别嘌醇致不良反应的有效文献95篇,并按患者性别、年龄、原患疾病与过敏史、给药途径、累及系统/器官及临床表现等方面进行统计分析。结果:收集别嘌醇所致不良反应114例中,皮肤损害80例,消化系统损害10例;其发生ADR时间最早为用药后8 h,最迟为用药2个月后;预后除造成13例死亡,95例经停药、对症治疗后均好转。结论:别嘌醇引起的不良反应临床表现复杂多样,其发生与多种因素有关,最严重的可能导致死亡,值得关注。
[Abstract]:Objective: to explore the regularity and characteristics of adverse reactions induced by allopurine alcohol, and to provide reference for clinical rational use of drugs. Methods: 95 effective literatures about adverse reactions induced by allopurine in 2000 / 2015 were searched by (CHKD) Journal full-text Database and Wanfang Database of Chinese Hospital knowledge Warehouse of China knowledge Network (CNKI), and according to the sex and age of the patients, The history of primary diseases and allergies, the route of administration, the involvement of system / organ and clinical manifestations were statistically analyzed. Results: among 114 cases of adverse reactions caused by allopurinol, 80 cases were skin damage and 10 cases were digestive system damage, the earliest time of ADR was 8 hours after treatment, and the latest was 2 months after treatment. The prognosis resulted in 13 cases of death and 95 cases of drug withdrawal, all of which improved after symptomatic treatment. Conclusion: the clinical manifestations of adverse reactions induced by allopurinol are complex and diverse, and their occurrence is related to many factors, the most serious of which may lead to death, which is worth paying attention to.
【作者单位】：北京医院药学部;郑州大学附属郑州市中心医院;
【分类号】：R971.1

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