对静脉注射盐酸头孢他啶不良反应的特点及原因相关因素分析研究

发布时间：2019-06-10 20:14

【摘要】：目的分析研究静脉注射盐酸头孢他啶不良反应(ADR)的特点及原因相关因素。方法收集2012年5月~2015年7月本院收治的76例静脉注射盐酸头孢他啶所致不良反应患者的临床病历报告,对其药物不良反应受累器官系统分布、临床表现及年龄分布特点展开统计分析。结果 76例患者的年龄段以2~17岁(19.74%)、51~60岁(15.79%)、61~70岁(26.32%)、71~80岁(22.37%)为主,均高于其他年龄段发生率,差异具有统计学意义(P0.05);受累器官系统分布依次为皮肤系统(48.68%)、消化系统(30.26%)、神经系统(21.05%),主要临床表现为皮疹、瘙痒、恶心、腹痛、肢体发麻;ADR多发生于第一次用药时(86.84%)。结论静脉注射盐酸头孢他啶不良反应多见于婴幼儿、儿童及老年人群,易导致患者皮肤、消化等系统受损,临床应规范用药剂量及方法,以减少不良反应发生。
[Abstract]:Objective to analyze the characteristics and causes of adverse reactions (ADR) of ceftazidime Hydrochloride by intravenous injection. Methods the clinical records of 76 patients with adverse reactions caused by intravenous injection of ceftazidime Hydrochloride from May 2012 to July 2015 were collected and the organ system distribution of adverse drug reactions was analyzed. The clinical manifestations and age distribution characteristics were statistically analyzed. Results the main age groups of 76 patients were 2 years old 17 years old (19.74%), 51 years old 60 years old (15.79%), 61 years old 70 years old (26.32%), 71 years old 80 years old (22.37%), all of them were higher than other age groups, the difference was statistically significant (P 0.05). The distribution of involved organ system was skin system (48.68%), digestive system (30.26%) and nervous system (21.05%). The main clinical manifestations were rash, pruritus, nausea, abdominal pain and limb anaesthesia. Most of ADR occurred at the time of the first medication (86.84%). Conclusion the adverse reactions of ceftazidime Hydrochloride by intravenous injection are more common in infants, children and elderly people, and are easy to cause damage to the skin and digestive system of the patients. the dosage and method of ceftazidime Hydrochloride should be standardized in order to reduce the occurrence of adverse reactions.
【作者单位】：江苏省盐城市第一人民医院静脉用药调配中心;
【分类号】：R978

【参考文献】