肿瘤医院Ⅰ类切口手术围术期抗菌药物合理使用的干预研究

发布时间：2019-06-22 19:13

【摘要】：目的探讨肿瘤专科医院Ⅰ类切口手术围术期预防使用抗菌药物的干预效果,以降低手术切口感染的发生,提高临床合理使用抗菌药物水平。方法回顾性分析2011年9月-2012年8月肿瘤外科Ⅰ类切口手术患者240例,分为非干预组和干预组,各120例,根据抗菌药物合理应用评价标准,调查分析抗菌药物预防性应用情况,数据采用SPSS 13.0软件进行统计分析。结果干预组患者围手术期抗菌药物使用率及合理应用率分别为4.17%及96.67%,非干预组患者分别为35.83%及67.50%,两组比较差异有统计学意义(P0.05);非干预组患者围手术期抗菌药物不合理用药无适应证占30.00%、药物选择不当占26.67%、用量不当占6.67%、用药时机不当16.67%,干预组患者不合理用药为无适应证占2.50%、药物选择不当占0.83%,干预后抗菌药物的合理性限制显著提高。结论医院采用的干预措施,有效提高了Ⅰ类切口手术围术期抗菌药物的合理使用。
[Abstract]:Objective to investigate the intervention effect of preventing the use of antibiotics during perioperative operation of class I incision in tumor hospital in order to reduce the occurrence of incision infection and improve the level of rational use of antibiotics in clinic. Methods from September 2011 to August 2012, 240 patients undergoing class I incision surgery in tumor surgery were divided into non-intervention group (n = 120) and intervention group (n = 120). According to the evaluation criteria of rational use of antibiotics, the preventive use of antibiotics was investigated and analyzed. The data were statistically analyzed by SPSS 13.0 software. Results the utilization rate and rational use rate of antibiotics in the intervention group and the non-intervention group were 4.17% and 96.67% respectively, and 35.83% and 67.50% in the non-intervention group, respectively. there was significant difference between the two groups (P 0.05). In the non-intervention group, the irrational use of antibiotics accounted for 30.00%, the improper drug selection accounted for 26.67%, the improper dosage was 6.67%, and the timing was 16.67%. The unreasonable use of antibiotics in the intervention group accounted for 2.50% of the patients without indication, and the improper drug selection accounted for 0.83%. The reasonable limitation of antibiotics increased significantly after intervention. Conclusion the intervention measures adopted in hospital can effectively improve the rational use of antibiotics during perioperative period of class I incision surgery.
【作者单位】：南通大学附属肿瘤医院药学部;
【基金】：江苏省南通科技局基金资助项目(HS12945)
【分类号】：R969.3

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