当代抗生素发展的挑战与思考

发布时间：2019-06-24 12:07

【摘要】：本文回顾了曲折的抗生素发展历史要点,看到了抗生素耐药性对新药发展的影响,以及世界各国在后抗生素时代为新药和抗生素耐药研究所做出的贡献。面对21世纪抗生素发展的挑战,作者思考后认为需要从以下三方面研究予以重视:一是重视抗菌药物的耐药性研究,二是重视新一代抗菌药物的新靶标研究,三是重视新抗生素发现和开发的策略;同时建议利用世界和我国的微生物基因组计划,开展一些耐药微生物的基因组研究,从中发现一些微生物在耐药过程中的基因变化,为抗生素合理应用和新抗生素研发提供新的靶标、增加新的研究途径;还希望在实施这些发展策略时,政府、社会、学界和产业界,发挥各自的优势,承担更多的责任。在不同的激励机制下,希望21世纪抗生素研究开发和应用获得可喜的进展。
[Abstract]:This paper reviews the tortuous historical points of antibiotic development, sees the influence of antibiotic resistance on the development of new drugs, and the contributions made by countries all over the world to new drugs and antibiotic resistance research in the post-antibiotic era. In the face of the challenge of antibiotic development in the 21st century, the author thinks that attention should be paid to the following three aspects: one is to pay attention to the drug resistance of antibiotics, the other is to attach importance to the new target research of new generation antibiotics, and the third is to attach importance to the strategy of discovery and development of new antibiotics. At the same time, it is suggested that the genome research of drug-resistant microorganisms should be carried out by using the microbial genome project of the world and China, from which the genetic changes of some microorganisms in the process of drug resistance should be found, so as to provide new targets for the rational application of antibiotics and the research and development of new antibiotics, and to add new research ways. It is also hoped that in the implementation of these development strategies, the government, society, academia and industry will give full play to their respective advantages and bear more responsibilities. Under different incentive mechanisms, it is hoped that gratifying progress will be made in the research, development and application of antibiotics in the 21 st century.
【作者单位】：天津药物研究院释药技术与药代动力学国家重点实验室天津药物研究院新药评价研究中心;
【分类号】：R978.1

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