链霉菌CPCC 202950大米发酵中1个新的苯甲酰胺类化合物
发布时间：2019-06-27 09:29
【摘要】：采用硅胶柱色谱、凝胶柱色谱、闪式反相C_(18)柱色谱以及反相HPLC等多种色谱技术和方法,从链霉菌CPCC 202950大米发酵产物中分离得到8个化合物,借助理化性质和波谱学数据分析,鉴定其结构为3-[(3'-氨基-3'-氧丙-1'-烯-2'-基)氧]苯甲酰胺(1),间位-羟基苯甲酰胺(2),leptosphaepin(3),5-methyluracil(4),feruloylamide(5),对羟基苯乙酰胺(6),vanillamide(7),环-(L-缬氨酸-L-丙氨酸)(8)。其中化合物1为1个新的苯甲酰胺类化合物,2为新的天然产物。化合物1~8对HIV-1蛋白酶均没有明显的抑制作用,对Hela,HepG2和U2OS 3株肿瘤细胞株也未显示出明显的毒性(IC_(50)10μmol·L~(-1))。
[Abstract]:Eight compounds were isolated from rice fermentation products of Streptomyces CPCC 202950 by silica gel column chromatography, flash reversed phase C18 column chromatography and reverse phase HPLC. Their structures were identified as 3-[(3) amino-3 / Oxypropyl-1 / Ene-2] benzamides (1) by means of physical and chemical properties and spectroscopic data. M-hydroxybenzamide (2), leptosphaepin (3), 5-methyluracil (4), feruloylamide (5), p-hydroxyphenylacetamide (6), vanillamide (7), ring-(L-valine-L-alanine) (8). Compound 1 is a new benzamide compound and 2 is a new natural product. Compound 1 鈮，
本文编号：2506679
[Abstract]:Eight compounds were isolated from rice fermentation products of Streptomyces CPCC 202950 by silica gel column chromatography, flash reversed phase C18 column chromatography and reverse phase HPLC. Their structures were identified as 3-[(3) amino-3 / Oxypropyl-1 / Ene-2] benzamides (1) by means of physical and chemical properties and spectroscopic data. M-hydroxybenzamide (2), leptosphaepin (3), 5-methyluracil (4), feruloylamide (5), p-hydroxyphenylacetamide (6), vanillamide (7), ring-(L-valine-L-alanine) (8). Compound 1 is a new benzamide compound and 2 is a new natural product. Compound 1 鈮，
本文编号：2506679
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