基于开环聚合的两亲性树枝状共聚物在化疗方面的研究
发布时间：2019-08-03 19:09
【摘要】：基于开环聚合构建了一种新型树枝状共聚物(PEG-G3-PCL)作为药物载体,而该药物载体是由三代树枝状聚酯(PEG-G3-OH)引发己内酯(CL)开环聚合而成的。两亲性的PEG-G3-PCL能自组装成胶束,并且对化疗药物阿霉素(DOX)拥有较高的药物装载能力和包封率。体外药物释放的研究结果表明:该胶束能快速释放DOX,装载DOX的PEG-G3-PCL胶束具有良好的化疗效果,并且PEG-G3-PCL胶束几乎无毒。
[Abstract]:A novel dendrimer (PEG-G3-PCL) was constructed as drug carrier based on ring-opening polymerization. The drug carrier was prepared by ring-opening polymerization of caprolactone (CL) initiated by third generation dendritic polyester (PEG-G3-OH). Amphiphilic PEG-G3-PCL can self-assemble micelle and has high drug loading ability and entrapment efficiency for doxorubicin (DOX). The results of drug release in vitro showed that the micelle could rapidly release the PEG-G3-PCL micelle loaded with DOX by DOX, and had good chemotherapy effect, and the PEG-G3-PCL micelle was almost non-toxic.
【作者单位】： 华东理工大学材料科学与工程学院;
【分类号】：R979.1
，
本文编号：2522735
[Abstract]:A novel dendrimer (PEG-G3-PCL) was constructed as drug carrier based on ring-opening polymerization. The drug carrier was prepared by ring-opening polymerization of caprolactone (CL) initiated by third generation dendritic polyester (PEG-G3-OH). Amphiphilic PEG-G3-PCL can self-assemble micelle and has high drug loading ability and entrapment efficiency for doxorubicin (DOX). The results of drug release in vitro showed that the micelle could rapidly release the PEG-G3-PCL micelle loaded with DOX by DOX, and had good chemotherapy effect, and the PEG-G3-PCL micelle was almost non-toxic.
【作者单位】： 华东理工大学材料科学与工程学院;
【分类号】：R979.1
，
本文编号：2522735
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