我院动物骨多肽类药物致不良反应96例分析

发布时间：2019-08-09 12:10

【摘要】：目的:探讨动物骨多肽类药物所致不良反应(ADR)的发生特点及规律,为临床合理使用该类药物提供参考。方法:回顾性分析2009年1月-2016年6月我院动物骨多肽类药物ADR发生情况,对96例ADR从患者性别、年龄、涉及药品、发生时间、给药途径、累及器官/系统、关联性及转归等方面进行统计分析。结果:96例ADR(含17例严重的ADR)病例中,男女比例为1.34∶1;40岁以上患者居多(56.25%);ADR多发生在用药后15 min内(39.58%),以静脉滴注为主;ADR累及器官/系统主要为皮肤及其附件损害(34.81%),其次为呼吸系统损害(18.35%)和全身性损害(16.46%);ADR关联性为很可能的有41例(42.71%),可能的有55例(57.29%);出现ADR并给予停药或相应处理后43例(44.79%)患者痊愈,53例(55.21%)患者症状有所好转。结论:医护人员应掌握动物骨多肽类药物致ADR的发生规律及特点,加强合理用药管理及临床用药监护,以保障临床用药的安全性及有效性。
[Abstract]:Objective: to investigate the characteristics and regularity of adverse reactions (ADR) induced by bone polypeptide drugs in animals, and to provide reference for rational use of these drugs in clinic. Methods: the incidence of bone polypeptide drugs ADR in our hospital from January 2009 to June 2016 was analyzed retrospectively. the sex, age, time of occurrence, route of administration, involvement of organs / systems, correlation and prognosis of 96 cases of ADR were statistically analyzed. Results: in 96 cases of ADR (including 17 cases of severe ADR), the majority of patients over 40 years old were male to female (56.25%); ADR occurred within 15 min after treatment (39.58%), mainly intravenous drip, ADR involved mainly skin and its adnexal lesions (34.81%), followed by respiratory system damage (18.35%) and systemic damage (16.46%). 41 cases (42.71%) were likely to be associated with ADR, 55 cases (57.29%) were likely to be associated with ADR, 43 cases (44.79%) were cured after ADR or corresponding treatment, and 53 cases (55.21%) had improved symptoms. Conclusion: medical and nursing staff should master the occurrence regularity and characteristics of ADR induced by bone polypeptide drugs in animals, and strengthen the management of rational drug use and clinical drug use monitoring in order to ensure the safety and effectiveness of clinical drug use.
【作者单位】：河南省洛阳正骨医院(河南省骨科医院)临床药学研究室;
【分类号】：R977

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