氟比洛芬酯联合地塞米松超前镇痛用于尘肺病肺灌洗临床观察

发布时间：2018-01-17 20:14

本文关键词：氟比洛芬酯联合地塞米松超前镇痛用于尘肺病肺灌洗临床观察　出处：《中国职业医学》2017年03期 　论文类型：期刊论文

【摘要】：目的观察氟比洛芬酯(FPA)联合地塞米松超前镇痛用于尘肺病大容量肺灌洗的临床效果。方法采用随机数字表法,将90例需行大容量肺灌洗的尘肺病患者随机分为联合给药组、FPA组和对照组,每组30例。联合给药组患者术前2 h静脉注射2 mg/kg体质量FPA注射液与10 mg地塞米松,FPA组患者术前静脉注射2 mg/kg体质量FPA注射液,对照组患者术前注射0.9%氯化钠溶液2 m L。比较3组患者术后2、6、8、12、24 h的疼痛视觉模拟法评分(VAS)、舒适评分(BCS)及术后24 h不良反应发生情况。结果在术后5个时间点,联合给药组患者VAS和BCS评分均高于对照组和FPA组(P0.01);联合给药组患者VAS评分呈随着术后时间增加而减少的趋势(P0.05),BCS评分呈随着术后时间增加而增加的趋势(P0.05)。联合给药组患者术后24 h恶心呕吐、头晕嗜睡、咽喉痛和皮肤瘙痒的发生率均低于对照组和FPA组(P0.017)。结论 FPA联合地塞米松超前镇痛是一种安全有效的缓解尘肺病患者大容量肺灌洗术后疼痛的治疗方法。
[Abstract]:Objective to observe the clinical effect of flurbiprofen (FPA) combined with dexamethasone (Dexamethasone) preemptive analgesia in large volume lung lavage of pneumoconiosis. A total of 90 patients with pneumoconiosis who needed large volume lung lavage were randomly divided into two groups: the combined administration group and the control group. 30 patients in each group were treated by intravenous injection of 2 mg/kg body mass FPA injection and 10 mg dexamethasone 2 hours before operation. The patients in FPA group were injected with 2 mg/kg body mass FPA injection before operation, and those in control group were injected with 0.9% sodium chloride solution 2 mL before operation. Visual analogue pain score (VASA), comfort score (BCSS) and adverse reaction (ADRs) at 24 h after operation were evaluated. Results the results were at 5 time points after operation. The scores of VAS and BCS in the combined administration group were higher than those in the control group and FPA group (P 0.01). The VAS score of the patients in the combined administration group decreased with the increase of postoperative time (P0.05). The BCS score increased with the increase of postoperative time (P 0.05). The patients in the combined administration group were nausea and vomiting, dizziness and lethargy 24 hours after operation. The incidence of sore throat and pruritus was lower than that of control group and FPA group (P0.017). Conclusion FPA combined with dexamethasone preemptive analgesia is a safe and effective method for relieving postoperative pain in patients with pneumoconiosis.
【作者单位】：广西壮族自治区人民医院麻醉科;
【基金】：国家自然科学基金(81360369) 广西壮族自治区卫生厅自筹科研项目(Z2012259)
【分类号】：R135.2
【正文快照】： 尘肺病是由于在职业活动中长期吸入生产性粉尘并在肺内潴留而引起的以肺组织弥漫性纤维化为主的全身性疾病。大容量全肺灌洗术是尘肺病的有效治疗方法之一,目前已在临床应用多年[1-2]。良好的麻醉方法对全肺灌洗术的安全和效果起着关键作用。氟比洛芬酯(Flurbiprofen axetil,F

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