浙江省婴儿麻疹病例分布特征和危险因素研究

发布时间：2018-02-12 19:55

本文关键词： 婴儿麻疹流行病学特征危险因素　出处：《中国疫苗和免疫》2015年02期 　论文类型：期刊论文

【摘要】：目的了解婴儿麻疹病例分布特征和发病危险因素,为探讨针对性的预防控制措施提供参考。方法分析浙江省2009~2012年婴儿麻疹病例的分布特征,用χ2检验比较分布差异;以监测系统报告的麻疹确诊病例为病例组,非麻疹病例为对照组,开展频数匹配的病例对照研究,用Logistic回归分析危险因素。结果浙江省2009~2012年婴儿麻疹病例占总病例数的38.80%,6~8月龄病例占婴儿麻疹的58.48%。麻疹病例的男女性别比为1.95∶1.00,医院暴露比例为46.20%,有咳嗽、口腔黏膜斑和卡他症状的比例分别为88.28%、39.72%和78.82%。多因素分析显示,8~11月龄麻疹病例中含麻疹成分疫苗(Measles-containing Vaccine,MCV)免疫史有统计学意义,比值比(Odds Ratio,OR)=0.49,95%可信区间(Confindence Interval,CI):0.27~0.89;0~7月龄发病危险因素则是在发病地居住时间3个月、出疹性病例接触史有统计学意义,OR分别为2.07(95%CI:1.21~3.52)、4.87(95%CI:1.62~14.62)。结论婴儿麻疹病例症状相对较重,流动人口、接触史和医院暴露等是危险因素,接种MCV是8~11月龄婴儿的有效保护措施。建议提高8月龄MCV及时接种率,加强流动儿童管理,减少医疗机构的暴露及出疹性病例的接触机会。
[Abstract]:Objective to understand the distribution characteristics and risk factors of measles cases in infants, and to provide a reference for the prevention and control measures. Methods the distribution characteristics of infant measles cases from 2009 to 2012 in Zhejiang Province were analyzed and the distribution differences were compared by 蠂 2 test. With confirmed measles cases reported by the surveillance system as the case group and non-measles cases as the control group, a frequency-matched case-control study was carried out. Results from 2009 to 2012, 38.80 cases of infant measles accounted for 58.48% of the total cases in Zhejiang Province. The sex ratio of measles cases was 1.95: 1.00, the hospital exposure ratio was 46.20 and there was cough. The rates of oral mucosal plaque and kalta-containing symptoms were 88.289.72% and 78.82%, respectively. Multivariate analysis showed that the immunization history of measles vaccine Measles-containing vaccine was statistically significant. The odds ratio of odds ratio to odds ratio is 0.49% 95% confidence intervalence CI: 0.270.89 / 0 0 month old risk factor is three months in the place of onset, the OR of contact history of rash cases is 2.07 ~ 95% CI: 1.213.52N 4.8795% 1.62i = 14.62 .Conclusion the symptoms of measles cases in infants are relatively serious and the floating population, the risk factors are relatively serious, and the incidence of measles in infants is relatively serious, and the risk factors are as follows: 1. 7% to 95% CI: 1.21 3.52% 4.8795% 1. 62% 1. 62%. Conclusion: the incidence of measles in infants is relatively severe, and the incidence of measles is relatively severe. Exposure history and hospital exposure were risk factors, and inoculation of MCV was an effective protective measure for 8-month old infants. It was suggested that the timely vaccination rate of 8-month-old MCV should be increased, the management of floating children should be strengthened, and the exposure of medical institutions should be reduced and the chance of exposure to rash cases should be reduced.
【作者单位】：浙江省疾病预防控制中心;
【分类号】：R725.1;R181.3

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