利用比例失衡分析方法分析无细胞百日咳-白喉-破伤风联合疫苗预防接种异常反应可疑信号

发布时间：2018-02-12 20:09

本文关键词： 比例失衡分析无细胞百日咳-白喉-破伤风联合疫苗预防接种异常反应信号　出处：《中国疫苗和免疫》2015年03期 　论文类型：期刊论文

【摘要】：目的利用数据挖掘技术中的4种常见的比例失衡分析方法(Disproportionality Analysis,DPA),分析无细胞百日咳-白喉-破伤风联合疫苗(Diaphtheria,Tetanus and Acellular Pertussis Combined Vaccine,DTa P)预防接种异常反应的可疑信号。方法利用DPA频数法中的比例报告比(Proportional Reporting Ratio,PRR)和报告比值比(Reporting Odds Ratio,ROR)及贝叶斯法中的贝叶斯置信传播神经网络(Bayesian Confidence Propagation Neural Network,BCPNN)和模糊贝叶斯伽马-泊松收缩论(Empirical Bayes Gamma-Poisson Shrinker,GPS)方法,对2011~2013年中国疑似预防接种异常反应信息管理系统中报告发生的有明确诊断的DTa P预防接种异常反应进行分析,检测其预防接种异常反应的可疑信号。结果 20 377例有明确诊断的预防接种异常反应个案参与分析,其中DTa P占16.13%。使用PRR和ROR方法提示,2011~2013年DTa P有6个可疑预防接种异常反应信号,使用BCPNN和GPS方法提示,2011~2013年DTa P有4个可疑预防接种异常反应信号。4种方法发现的可疑预防接种异常反应信号集中在接种DTa P后的血管性水肿和无菌性脓肿。结论无菌性脓肿和血管性水肿为已知的DTa P的预防接种异常反应,利用DPA方法发现的可疑信号是风险的警示,但仅仅提示存在报告数量上的关联,是否是真实的安全性问题,需要经过包括医学评估在内的严谨的信号评价过程。
[Abstract]:Objective to analyze the suspicious signals of acellular pertussis diphtheria and Acellular Pertussis Combined vaccine against abnormal response to vaccination by using four common methods of proportion imbalance analysis in data mining. Methods\\\; Using the proportional Reporting ratio (DPA) and reporting Odds ratio (ROR) and Bayesian Confidence Propagation Neural Network (BCPNN) and Bayesian Bayesian Confidence Propagation Neural Network (BCPNN) and Bayesian Gamma-Poisson contraction Theory (Bayesian Bayes Gamma-Poisson contraction), the Bayesian Confidence Propagation Neural neural network (BCPNN) and the Bayesian Confidence Propagation Neural neural network (BCPNN), and the Bayesian Confidence Propagation Neural neural network (BCPNN) and the Bayesian Gamma Poisson contraction theory (Bayesian Gamma Poisson contraction theory), respectively. The abnormal response of DTa P in Chinese suspected vaccination abnormal response information system from 2011 to 2013 was analyzed. Results 20 377 cases of abnormal vaccination reaction with definite diagnosis participated in the analysis. PRR and ROR methods were used to indicate that there were 6 abnormal response signals in DTa P from 2011 to 2013. BCPNN and GPS methods were used to indicate that there were 4 suspicious abnormal vaccination response signals in DTa P from 2011 to 2013. The abnormal response signals of 4 methods focused on vascular edema and aseptic abscess after inoculation of DTa P. conclusion\\\; Aseptic abscess and vascular edema were known to be abnormal responses to DTa P inoculation. The suspicious signal detected by DPA method is a warning of risk, but it only indicates that there is a correlation between the number of reports and whether it is a real security problem, which needs to go through a rigorous signal evaluation process including medical evaluation.
【作者单位】：中国疾病预防控制中心免疫规划中心;
【分类号】：R186

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