职业人群血清丙氨酸氨基转移酶参考区间的探讨

发布时间：2018-02-27 11:17

本文关键词： 职业健康监护职业有害因素丙氨酸氨基转移酶参考区间职业卫生标准　出处：《环境与职业医学》2015年01期 　论文类型：期刊论文

【摘要】：[目的]探讨职业性有害因素接触人群的血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)的参考区间,为相应卫生标准的制定提供基础数据。[方法]选取2013年1月1日—2013年12月31日至北京市预防医学研究中心职业卫生所进行职业健康检查、接触职业性肝损伤有害因素的2 023名在岗工人的职业健康检查资料进行回顾性研究。采用全自动生化分析仪进行血清ALT检测,采用腹部B超常规检查探查肝脏实质及肝内血管疾患情况,并进行统计分析。[结果]目标人群血清ALT水平为18 U/L(17 U/L,216 U/L),不同性别和年龄之间的血清ALT值差异具有统计学意义(P0.05)。排除肝脏器质性疾患的个体后,该职业人群中男性工人血清ALT值的单侧95%范围为5.0~62.2 U/L,高于现行标准(2013-08-01之前)(5~40 U/L)。血清ALT水平在41~60 U/L之间的男性工人的肝脏B超检查阳性率同血清ALT值61 U/L的男性工人相比较,差异无统计学意义。[结论]职业人群中男性血清ALT值的参考区间可参考卫生部制定的新标准。
[Abstract]:[objective] to study the reference interval of alanine aminotransferase (alt) in the exposed population with occupational harmful factors. [methods] from January 1st 2013 to December 31st 2013, occupational health examination was carried out at the Occupational Health Institute of Beijing Preventive Medical Research Center. The data of occupational health examination of 2 023 workers exposed to harmful factors of occupational liver injury were retrospectively studied. Serum ALT was detected by automatic biochemical analyzer. The liver parenchyma and intrahepatic vascular diseases were detected by routine abdominal ultrasonography. [results] the serum ALT level of the target population was 18 U / L ~ (17) U / L ~ (16) U / L ~ (-1), and the difference of serum ALT between different sexes and ages was statistically significant (P < 0.05). The serum ALT level of male workers in this occupational group ranged from 5.0 to 62.2 U / L on one side, which was higher than that of 540 UL / L before the current standard before 2013-08-01. The positive rate of liver B ultrasound in male workers whose serum ALT level was between 41U / L and 60UL was compared with that of male workers whose serum ALT value was 61UL. [conclusion] the reference range of male serum ALT in occupational population may refer to the new standard developed by Ministry of Health.
【作者单位】：北京市疾病预防控制中心;北京市预防医学研究中心职业卫生所;
【分类号】：R131

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