菊粉类果聚糖对人体脂、糖代谢的影响—随机对照试验的Meta分析

发布时间：2018-03-03 16:49

本文选题：菊粉类果聚糖　切入点：动脉粥样硬化　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：采用Meta分析的方法,系统评价所有关于菊粉类果聚糖对人体脂、糖代谢的影响的随机对照试验结果,为动脉粥样硬化性心血管疾病和糖尿病防治饮食策略的制定提供依据。具体内容包括：①菊粉类果聚糖对动脉粥样硬化相关血脂(HDL-C、TG、LDL-C)的影响的Meta分析；②菊粉类果聚糖对人体糖代谢主要指标(FPG、HbA1c)的影响的Meta分析。方法：两个部分的Meta分析都主要经过以下步骤：全面检索数据库中的相关文献(第一部分检索的数据库有PubMed、Embase、中国知网、中国生物医学文献数据库、中文科技期刊数据库和万方数据知识服务平台,第二部分检索的数据库有PubMed、Embase、Medline、 Cochrane),按照预先制定的纳入和排除标准筛选文献,之后进行质量评价(JADAD量表)和数据提取,最终采用Cochrane协作网提供的Review Manager5.1软件和Statal1.0软件进行Meta分析和发表偏倚的检测。结果：①菊粉类果聚糖对动脉粥样硬化相关血脂的影响的Meta分析：最终纳入22篇文献,总样本数为822例,实验组413例,对照组409例。分析结果显示,菊粉类果聚糖对HDL-C、TG和LDL-C水平影响的合并加权均数差(Weighted mean difference, WMD)值及95%可信区间(Confidence interval, CI)分别为0.05 mmol/L (0.01,0.08)、-0.08 mmol/L(-0.14,-0.01)和-0.16 mmol/L (-0.25,-0.06),即HDL-C水平显著升高,TG、LDL-C水平显著降低。亚组分析结果显示：血脂异常组TG水平显著降低0.17 mmol/L;糖尿病组HDL-C水平显著升高0.15 mmol/L,TG水平显著降低0.30 mmol/L,其他结果的改变均无统计学意义。②菊粉类果聚糖对人体糖代谢主要指标的影响的Meta分析：共纳入16篇文献,总样本数为536例,实验组271例,对照组265例。分析结果显示,菊粉类果聚糖对FPG和HbA1c水平影响的合并WMD值及95%C1分别为-0.11 mmol/L(-0.21,-0.01)和-0.36%(-0.76,0.04)。亚组分析结果显示：糖尿病组FPG水平显著降低0.72 mmol/L,95%CI为(-1.01,-0.42)；HbAlc水平显著降低0.59%,95%CI为(-0.92,-0.25)。非糖尿病组结果的改变无统计学意义。结论：①在脂代谢调节方面,菊粉类果聚糖补充可使人体血清HDL-C水平增高,TG和LDL-C水平降低。其中血脂异常人群、糖尿病人群获益更多,前者TG水平降低更明显,后者不仅TG水平降低更明显,同时HDL-C水平增高也更明显。每日摄食菊粉类果聚糖14g左右可能起到防治动脉粥样硬化性心血管疾病的作用。②在糖代谢调节方面,膳食补充菊粉类果聚糖,FPG水平降低,HbAlc水平的改变无统计学意义。但是对于糖尿病人群,FPG和HbAlc水平的降低均有统计学意义,并且降低幅度比总人群明显大。每日摄食菊粉类果聚糖13g左右可能在糖尿病及其并发症的防治中发挥有益的作用。
[Abstract]:Objective: to evaluate the results of all randomized controlled trials on the effects of inulin fructan on human lipid and glucose metabolism by Meta analysis. To provide the basis for the formulation of dietary strategies for the prevention and treatment of atherosclerotic cardiovascular diseases and diabetes mellitus. The specific contents include the Meta analysis of the effect of 1% inulin fructan on atherosclerotic related lipids (HDL-C). Meta analysis on the effect of HbA1c on human glucose metabolism. Methods: the two parts of Meta analysis mainly go through the following steps: search the relevant documents in the database (the first part of the database is PubMeden Embase, China knowledge Network, the first part of the database, China Biomedical Literature Database, Chinese Sci-tech Journals Database and Wanfang data knowledge Service platform. The second part of the search database includes PubMeden Embase Medline, Cochranegne, according to the pre-established inclusion and exclusion criteria for the screening of literature, Then the quality evaluation and data extraction were carried out with JADAD scale. Finally, Meta analysis and publication bias detection were performed with Review Manager5.1 and Statal1.0 software provided by Cochrane Cooperative Network. Results the Meta analysis of the effect of fructan on atherosclerotic blood lipid was carried out. The total number of samples was 822, 413 in the experimental group and 409 in the control group. The combined weighted mean difference (WMD) and confidence interval (CI) of inulin fructosans on HDL-Cn TG and LDL-C levels were 0. 05 mmol / L (0. 01 ~ 0. 08 mmol / L -0. 08 mmol / L ~ 0. 014 -0. 01) and -0. 16 mmol / L ~ 0. 25 ~ 0. 06 mmol-0. 06, respectively. The results of subgroup analysis showed that the level of HDL-C increased significantly. The results showed that TG level in dyslipidemia group was significantly decreased by 0.17 mmol / L, HDL-C level in diabetes group was significantly increased by 0.15 mmol / L and decreased significantly by 0.30 mmol / L, and no significant change in other results was found. 2. 2 effect of inulin on the main indexes of glucose metabolism in human body. Meta analysis: a total of 16 articles, The total number of samples was 536, 271 in the experimental group and 265 in the control group. The combined WMD value and 95 of inulin fructan on FPG and HbA1c levels were -0.11 mmol / L ~ (-1) -0.21 ~ (-1) and -0.36 ~ (-6) ~ 0.04 ~ (0.04), respectively. The results of subgroup analysis showed that the FPG level of diabetic group was significantly lower than that of non-diabetic group by -1.01-0.42HbAlc (-0.59mmol / L ~ (95) CI = -0.92- 0.25) respectively. The subgroup analysis showed that the level of FPG was significantly decreased by -0.72 mmol / L ~ (95) CI, -1.01-0.42HbAlc level in diabetes mellitus group. The changes were not statistically significant. Conclusion: 1 is involved in lipid metabolism regulation. Inulin fructan supplementation increased serum HDL-C levels and decreased TG and LDL-C levels, especially in patients with dyslipidemia and diabetes mellitus, the former had a more significant decrease in TG level, and the latter had more significant decrease in TG level. At the same time, the increase of HDL-C level was also more obvious. Ingesting about 14g of inulin fructan per day might play a role in preventing and treating atherosclerotic cardiovascular diseases. 2. In the regulation of glucose metabolism, There was no significant change in FPG and HbAlc levels in diabetic patients after dietary supplementation of FPG and FPG, but there was no significant difference in the level of HbAlc in diabetic patients, but there was no significant difference in the levels of FPG and HbAlc in diabetic patients. The rate of decrease was obviously larger than that of the total population, and about 13g of fructan intake per day might play a beneficial role in the prevention and treatment of diabetes mellitus and its complications.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R151.3

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