锰中毒动物模型研究与应用进展

发布时间：2018-03-05 09:21

本文选题：锰中毒　切入点：动物模型　出处：《中国职业医学》2017年02期 　论文类型：期刊论文

【摘要】：正锰是机体必需的微量元素之一,但是过量的锰蓄积在大脑可引起运动障碍、肌张力增高和震颤麻痹等一系列帕金森样综合征,并且呈不可逆进行性发展~([1-3])。目前国内外关于慢性锰中毒的机制尚未阐明,且对该疾病亦无特效的治疗方法。动物实验作为机制研究的重要手段应用广泛,本文就近期锰中毒实验研究中有关动物模型的文献资料作综述。
[Abstract]:Positive manganese is one of the essential trace elements in the body, but excessive manganese accumulation in the brain can lead to a series of Parkinson's syndrome, such as dyskinesia, increased muscle tension and tremor paralysis. At present, the mechanism of chronic manganese poisoning has not been elucidated at home and abroad, and there is no effective treatment for the disease. Animal experiment is widely used as an important means of mechanism research. This paper reviews the literature on animal models in recent experimental studies of manganese poisoning.
【作者单位】：济南大学山东省医学科学院医学与生命科学学院;山东省职业卫生与职业病防治研究院;
【基金】：国家自然科学基金面上项目(81472933)
【分类号】：R135.1;R-332

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