海南省46例类鼻疽的流行病学特征与临床分析

发布时间：2018-03-06 16:07

本文选题：类鼻疽　切入点：类鼻疽伯克霍尔德菌　出处：《中国病原生物学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的分析海南地区类鼻疽伯克霍尔德菌感染的临床特点及耐药性,为类鼻疽的预防和治疗提供科学依据。方法收集2000年1月-2012年12月海南省人民医院经培养鉴定的46株类鼻疽伯克霍尔德菌标本的相关资料,分析类鼻疽患者的分布特征、临床表现、病死率、耐药性及治疗效果。结果类鼻疽伯克霍尔德菌感染者多分布于省内沿海地区,内陆无或少见,病死率较高(占28.26%);中年发病较多,男、女性患者比例为43∶3;患者通常伴有某些基础性疾病,其中糖尿病患者为32例,占69.57%;临床表现多样,症状以败血症多见(占76.09%);细菌对亚胺培南、美罗培南和哌拉西林/他唑巴坦较敏感,敏感率分别为100.00%、94.59%和91.89%,以亚胺培南为主的综合治疗效果良好。结论类鼻疽伯克霍尔德菌感染易被误诊和漏诊,医生应该提高类鼻疽疾病识别水平,早期进行细菌培养和药敏试验,并及时选用敏感的抗生素治疗,以提高治愈率。
[Abstract]:Objective to analyze the clinical characteristics and drug resistance of Borkholderma mallei infection in Hainan area. Methods from January 2000 to December 2012, 46 strains of Borkholderia mallei from Hainan Provincial people's Hospital were collected, and the distribution characteristics of the patients were analyzed. Results the clinical manifestations, mortality, drug resistance and therapeutic effect were found in the coastal areas of the province, and there were no or few cases in the inland area. The mortality rate was higher (28.26%), and there were more cases in middle age (male). The proportion of female patients is 43: 3; patients usually have some basic diseases, including 32 cases of diabetes mellitus (69.57%), various clinical manifestations and most symptoms of septicemia (76.09%). Meropenem and piperacillin / tazobactam were sensitive, and the sensitive rates were 100.59% and 91.89%, respectively. Doctors should improve the level of identification of melioidosis, early bacterial culture and drug sensitivity test, and select sensitive antibiotics in time to improve the cure rate.
【作者单位】：海南医学院热带医学与检验医学院;海南省人民医院检验科;
【基金】：国家自然科学基金项目(No.81360240,81560002)
【分类号】：R181.3;R516

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