黄酒多糖对免疫缺陷小鼠血清免疫相关因子的影响

发布时间：2018-03-15 22:30

本文选题：黄酒多糖　切入点：免疫缺陷小鼠　出处：《食品科学》2015年05期 　论文类型：期刊论文

【摘要】：研究黄酒多糖对免疫缺陷小鼠血清免疫因子的影响。选择健康昆明小鼠,适应性喂养4 d后,分成5组:空白组、环磷酰胺(cyclophosphamide,CY)模型组、CY+黄酒多糖(低、中、高剂量)组,每组10只。黄酒多糖按高、中、低3个剂量(50、100、200 mg/(kg·d),均以体质量计)给小鼠灌胃,1次/d,连续给药14 d,空白组和CY模型组给予生理盐水。第19天除空白组,其余4组腹腔注射环磷酰胺,连续4 d。处死小鼠,眼眶取血,测定血清中白细胞介素-6(interleukin 6,IL-6)、干扰素-γ(interferon-γ,IFN-γ)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、免疫球蛋白(Ig A、Ig M、Ig G)、补体(C3、C4)水平。结果表明,与CY组相比,黄酒多糖能提高IL-6、IFN-γ、TNF-α、免疫球蛋白(Ig A、Ig M、Ig G)和补体(C3、C4)水平,并且随着低中高剂量效果依次增加。由此说明,黄酒多糖能提高免疫缺陷小鼠的免疫功能。
[Abstract]:To study the effect of yellow rice wine polysaccharides on serum immune factors of immunodeficient mice, healthy Kunming mice were selected and fed adaptively for 4 days. After 4 days of adaptive feeding, they were divided into five groups: blank group, Cyclophosphamide CYD model group, CY polysaccharide group (low, medium and high dosage). There were 10 rats in each group. The polysaccharides of yellow rice wine were given to mice by oral administration for 14 days, and saline was given to the blank group and CY model group on the 19th day, except for the blank group on the 19th day except for the blank group. The other four groups received intraperitoneal injection of cyclophosphamide for 4 days. The mice were sacrificed and blood was collected from the orbit. The serum levels of interleukin-6 interleukin 6, interferon- 纬 -interferon- 纬, tumor necrosis factor- 伪 tumor necrosis factor- 伪 tNF- 伪, immunoglobulin Ig Ig MG GG, complement C3C4) were determined. Compared with CY group, yellow rice wine polysaccharides could increase the levels of IL-6 IFN- 纬 -TNF- 伪, immunoglobulin Ig (Ig) and complement C3C4, and increased in turn with the low, medium and high dose effect, which indicated that rice wine polysaccharides could improve the immune function of immunodeficient mice.
【作者单位】：江南大学食品学院;江南大学粮食发酵工艺与技术国家工程实验室;国家黄酒工程技术研究中心;
【基金】：国家高技术研究发展计划(863计划)项目(2013AA102203-06) 国家自然科学基金面上项目(31271839)
【分类号】：R151

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