三种手消毒剂启用后维持杀菌能力时间的实验评价

发布时间：2018-03-21 19:26

本文选题：手消毒剂　切入点：杀菌能力　出处：《中华医院感染学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的了解三种手消毒剂启用后有效杀菌时间维持的实验检测,为临床制定手消毒剂启用后的有效使用期提供实验依据。方法随机抽取本市某三甲医院临床科室连续使用6个月的手消毒剂(3M爱护佳免洗手消毒液,有效成分葡萄糖酸氯己定和乙醇)样本3M-1、3M-2、3M-3,实验室模拟连续使用近3个月的手消毒剂G1(伽玛免洗手消毒液,有效成分葡萄糖酸氯己定和乙醇)、G2(伽玛无醇免洗手消毒液,有效成分复合双链季铵盐化合物),按卫生部《消毒技术规范》(2002版)方法进行细菌悬液定量杀菌试验。结果所有5个样本对大肠埃希菌、金黄色葡萄球菌作用30、60、90s的杀灭对数值均下降8以上;样本3M-1、3M-2、3M-3、G1对白念珠菌的杀灭对数值均达到7个对数值以上;G2样品对白念珠菌的杀灭能力,作用30s达到6个对数值,作用90s则可上升至7个对数值;对白念珠菌杀灭效果,葡萄糖酸氯己定和乙醇配方略优于复合双链季铵盐化合物。结论葡萄糖酸氯己定和乙醇与复合双链季铵盐化合物配方的手消毒剂,无论是医疗机构临床使用,还是实验室模拟使用,启用后的连续使用能维持较长的有效杀灭时间。
[Abstract]:Objective to investigate the effective germicidal time maintenance of three hand disinfectants. To provide the experimental basis for the effective life of hand disinfectant after it was put into use. Methods the hand disinfectant Jiaojiajiao 3M handwashing disinfectant, which was continuously used for 6 months, was randomly selected from the clinical department of a third Class A Hospital in this city. The effective components of chlorhexidine gluconate and ethanol were 3M-1 + 3M-2m-2 3M-3, the laboratory simulated the use of the hand disinfectant G1 (Gamma free hand disinfectant), the active components chlorhexidine gluconate and ethanol G2 (Gamma No Alcohol Free hand disinfectant), The bacterial suspension quantitative germicidal test was carried out according to the method of the Ministry of Health (Ministry of Health, Technical Specification for Disinfection). Results all the 5 samples were for Escherichia coli. The logarithmic values of killing Candida albicans in samples of 3M-1, 3M-2M-2M-3M-3G-1 and above 7 logarithmic values were decreased by more than 8 for 30 seconds after exposure of Staphylococcus aureus to 30 ~ 60 seconds, and the logarithmic values of killing Candida albicans in samples of above logarithmic values reached 6 logarithms for 30s. 90 s can increase to 7 logarithmic values, and the killing effect of Candida albicans, The formula of chlorhexidine gluconate and ethanol is slightly superior to that of compound double chain quaternary ammonium salt compound. Conclusion the hand disinfectant of chlorhexidine gluconate and ethanol and compound double chain quaternary ammonium salt formula, whether it is used in clinic in medical institution, is better than that of compound double chain quaternary ammonium salt compound. Or laboratory simulation use, continuous use after the use can maintain a longer effective kill time.
【作者单位】：杭州市疾病预防控制中心消毒与病媒生物防制所;
【基金】：浙江省重点科技创新团队基金资助项目(2011R50021) 杭州市科技发展计划基金资助项目(20130733Q32)
【分类号】：R187

【相似文献】