费县地区孕母产前和新生儿维生素D营养状况及其相关因素分析

发布时间：2018-03-24 06:10

本文选题：维生素D　切入点：孕妇　出处：《青岛大学》2017年硕士论文

【摘要】：目的:研究费县地区孕母产前与新生儿维生素D营养状况及其影响因素,分析孕母产前与新生儿维生素D营养状况及其影响因素之间的关系。方法:随机选取2016年1月-2016年12月在费县人民医院进行查体和生育的孕母和其所分娩的新生儿各100例,作为研究对象。通过调查问卷和查看病史资料收集孕母的相关信息、孕期身体状况和分娩后新生儿相关情况。征得患者同意后进行采样,应用液相色谱串联质谱法来检测血清维生素D水平。有关孕母分娩及新生儿出生情况,从保健手册上查阅得到。不同季节孕母及新生儿维生素D水平的差异采用多样本秩和检验,多因素分析采用二分类logistic回归,通过Spearman相关及偏相关分析孕母-新生儿25-(OH)D的相关性。结果:本研究共纳入100例孕母及其对应的100例新生儿,具体结果如下:1、孕母平均25-(OH)D水平为:16.92士6.82 ng/ml,其中有87%的孕母维生素D缺乏或不足。2、新生儿平均25-(OH)D水平为:17.36士5.19 ng/ml,其中有90%的新生儿维生素D缺乏或不足。3、孕母及新生儿25-(OH)D水平存在明显的季节差异,冬春季平均14.73士6.52ng/ml,夏秋季平均为18.41士5.24ng/ml。4、除季节因素外,孕期补充复合维生素和孕期多晒太阳有利于孕期维持维生素D处于高水平。5、孕母和新生儿脐血25-(OH)D水平呈正相关性。结论:1、费县地区孕母与新生儿普遍存在维生素D缺乏或不足,并且冬春季低于夏秋季。表明该地区孕妇应该适当补充维生素D和孕期多晒太阳有利于孕期维持维生素D处于正常合理水平。2、孕母-新生儿25-(OH)D水平呈正相关性,表明母体内的维生素D水平影响着新生儿维生素D水平。
[Abstract]:Objective: to study the nutritional status of vitamin D in pregnant mothers and newborns in Fei County and its influencing factors. The relationship between prenatal and neonatal vitamin D nutritional status and its influencing factors were analyzed. Methods: 100 pregnant mothers and 100 newborns were randomly selected from January 2016 to December 2016 in Feixian people's Hospital for physical examination and birth. As the research object. Collect the relevant information about the pregnant mother, the physical condition during pregnancy and the related situation of the newborn after delivery by questionnaire and check the medical history data. Sample with the consent of the patient. Serum vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS). The differences of vitamin D levels between pregnant mothers and newborns in different seasons were analyzed by multi-sample rank sum test and multivariate analysis by two-classification logistic regression. Spearman correlation and partial correlation were used to analyze the relationship between pregnancy and neonatal 25-(OH)D. Results: 100 pregnant mothers and their corresponding 100 newborns were included in this study. The results are as follows: 1. The average 25-(OH)D level of pregnant mothers is: 16.92 + 6.82 ng / ml, of which 87% of pregnant mothers are deficient or deficient in vitamin D, while the average 25-(OH)D level of newborns is: 17.36 卤5.19 ng / ml, 90% of newborns have vitamin D deficiency or deficiency of .3. There were significant seasonal differences in 25-(OH)D levels in newborns. The average value in winter and spring was 14.73 卤6.52 ng / ml, and that in summer and autumn was 18.41 卤5.24 ng / ml. Supplementation of multivitamins during pregnancy and multiple sun exposure during pregnancy were beneficial to maintaining a high level of vitamin D during pregnancy. There was a positive correlation between 25-(OH)D levels in umbilical cord blood of pregnant mothers and newborns. Conclusion Vitamin D deficiency or deficiency is common in pregnant mothers and newborns in Feixian area. And winter and spring are lower than in summer and autumn. The results indicate that pregnant women in this area should take appropriate vitamin D supplementation and more sun exposure during pregnancy to maintain a normal and reasonable level of vitamin D in pregnancy. The 25-(OH)D level between mother and newborn is positively correlated. The results showed that the vitamin D level in the mother affected the vitamin D level of the newborn.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R153.1

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