不同诱导物对内皮细胞氧化损伤作用的研究进展

发布时间：2018-04-04 15:09

本文选题：内皮细胞　切入点：氧化损伤　出处：《食品科学》2017年15期

【摘要】：高血压、动脉粥样硬化等心脑血管疾病的发病率逐年增加,这是严重危害人类健康生活的一类疾病,而内皮细胞氧化损伤往往是这些疾病早期的共同反应。不仅如此,一些治疗如物理治疗、心脏手术等会遗留一些影响内皮细胞功能的问题。因此,该领域研究者们对内皮细胞氧化损伤的机制研究越来越重视,并以此寻找合适的效应物如食品中的活性成分来抑制内皮细胞的氧化,减少和防治相关疾病的发生。本文综述了内皮细胞氧化损伤研究中几种常用诱导物如过氧化氢、氧化低密度脂蛋白、高糖、辐射等对内皮细胞氧化损伤的作用和特点,供研究人员根据研究方向选择合适的诱导物来建立内皮细胞氧化损伤模型,以此更有针对性地进行效应物的筛选及作用机制的研究。
[Abstract]:The incidence of cardiovascular and cerebrovascular diseases, such as hypertension and atherosclerosis, is increasing year by year, which is a serious harm to human health, and endothelial cell oxidative damage is often the early common reaction of these diseases.Not only that, some treatments such as physical therapy, cardiac surgery and so on will leave some problems affecting the function of endothelial cells.Therefore, researchers in this field pay more and more attention to the mechanism of endothelial cell oxidative damage, and find suitable effectors such as the active components in food to inhibit the oxidation of endothelial cells, reduce and prevent the occurrence of related diseases.In this paper, the effects and characteristics of several common inducers such as hydrogen peroxide, oxidized low density lipoprotein, high sugar and radiation on oxidative damage of endothelial cells were reviewed.For the researchers to select the appropriate inducer according to the research direction to establish the endothelial cell oxidative damage model, so as to more targeted screening of the effector and the mechanism of action.
【作者单位】：中南林业科技大学稻谷及副产物深加工国家工程实验室;
【基金】：国家自然科学基金青年科学基金项目(31201348);国家自然科学基金面上项目(31571874) 湖南省自然科学基金面上项目(2017JJ2410) 湖湘青年科技创新人才项目(2016RS3033) 粮油深加工与品质控制2011湖南省协同创新项目中南林业科技大学研究生教材建设项目(2015JC03)
【分类号】：R151

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