果糖和双酚A联合暴露对发育早期雄性大鼠摄食饮水和体重的影响

发布时间：2018-04-11 09:28

本文选题：果糖 + 双酚A　；参考：《环境与健康杂志》2017年07期

【摘要】：目的探讨双酚A(bisphenol A,BPA)和果糖单独或联合暴露对发育早期雄性大鼠摄食量、饮水量和体重的影响。方法将50只清洁级初断乳的Wistar雄性大鼠按体重随机分为5组,分别为对照组、13%果糖组、20%果糖组、BPA(1μg/ml)组和BPA(1μg/ml)+果糖(13%)组,每组10只,每笼3~4只饲养。采用自由饮水方式进行染毒,连续染毒8周,每天新鲜配制饮水。测定各组大鼠摄食量、饮水量和体重,并计算能量和蛋白质摄入量。结果与对照组比较,13%果糖组和20%果糖组大鼠的摄食量和蛋白质摄入量均明显减少,差异均有统计学意义(P0.05);13%果糖组和BPA+果糖组大鼠的饮水量明显增加,总热能摄入量也明显增高,差异均有统计学意义(P0.05);20%果糖组和BPA组大鼠的饮水量和总热能摄入量间比较,差异无统计学意义(P0.05);BPA+果糖组大鼠的饮水量和总能量摄入均明显高于BPA组,差异均有统计学意义(P0.05)。实验期间,各实验组大鼠体重与对照组比较,没有明显差异(P0.05)。结论 1μg/ml BPA和13%果糖单独或联合暴露对发育期雄性大鼠的体重没有明显影响;联合暴露组大鼠的摄食量和饮水量与13%果糖组一致,没有受到BPA的影响。
[Abstract]:Objective to investigate the effects of bisphenol A bisphenol (BPA) and fructose alone or in combination on the intake, water consumption and body weight of early developmental male rats.Methods Fifty freshly weaned Wistar male rats were randomly divided into 5 groups according to their body weight. They were divided into two groups: control group (n = 10), control group (n = 10), control group (n = 10, n = 10) and control group (n = 10, n = 34, n = 34 per cage, n = 10): control group (n = 10) with 20% fructose group (n = 10) or BPA(1 渭 g / ml group (n = 30).Free drinking water was used for 8 weeks. Fresh drinking water was prepared every day.Food intake, water intake and body weight were measured, and energy and protein intake were calculated.Results compared with the control group, the dietary intake and protein intake of the rats in the 13% fructose group and 20% fructose group were significantly decreased, and the difference was statistically significant. The drinking water and the total energy intake of the rats in the fructose group and BPA fructose group were significantly increased.There was no significant difference in water intake and total energy intake between 20% fructose group and BPA group. The water intake and total energy intake in P0.05% fructose group were significantly higher than those in BPA group, and the difference was statistically significant (P 0.05).During the experiment, there was no significant difference in body weight between the experimental group and the control group (P 0.05).Conclusion 1 渭 g/ml BPA and 13% fructose exposure alone or in combination have no significant effect on the body weight of developing male rats, and the intake and water consumption of the combined exposure group are the same as those of the 13% fructose group and are not affected by BPA.
【作者单位】：中国医科大学公共卫生学院儿少卫生与妇幼保健学教研室;
【基金】：辽宁省自然科学基金(2015020466)
【分类号】：R114

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