2014年广西1-29岁人群乙型肝炎血清流行病学调查及乙型肝炎疫苗接种情况分析

发布时间：2018-04-16 11:32

本文选题：乙型肝炎 + 血清流行病学　；参考：《中国疫苗和免疫》2017年04期

【摘要】：目的了解2014年广西1-29岁人群乙型肝炎(乙肝)病毒(HBV)血清流行病学特征。方法采用分层二阶段整群随机抽样方法抽取广西6个监测县(区)1-29岁常住人口开展问卷调查,采集血标本进行HBV血清学指标检测,进行流行病学分析。结果广西1-29岁人群HBV表面抗原(HBs Ag)、HBV表面抗体(Anti-HBs)、HBV核心抗体(Anti-HBc)阳性率分别为1.7%(标化值:2.6%)、67.3%(标化值:64.7%)、11.6%(标化值:17.0%)。HBs Ag、Anti-HBc阳性率随年龄增加而上升(x2=17.27,P=0.000;x2=123.84,P=0.000),Anti-HBs阳性率随年龄增加而下降(x2=25.08,P=0.000)。农村地区HBs Ag、Anti-HBc阳性率高于城市地区(x2=13.78,P=0.000;x2=15.83,P=0.000),但Anti-HBs阳性率低于城市地区(x2=73.42,P=0.000)。1 020名调查对象中乙肝疫苗(Hep B)接种率为82.6%。1-14岁儿童中不同年龄、居住地、出生地Hep B全程接种率及首剂次Hep B及时接种率均有显著性差异。接种过Hep B的人群HBs Ag阳性率显著低于无或不详接种史的人群。结论广西1-29岁人群特别是低年龄儿童HBs Ag携带率控制在较低水平。需加强新生儿Hep B及时接种和乙肝防控的健康教育。
[Abstract]:Objective to investigate the seroepidemiological characteristics of hepatitis B virus (HBV) in Guangxi population aged 1-29 years in 2014.Methods the stratified two-stage cluster random sampling method was used to select the resident population aged 1-29 years from 6 monitoring counties in Guangxi to carry out questionnaire survey. The blood samples were collected for the detection of HBV serological indexes and epidemiological analysis was carried out.The positive rate of HBs Agn Anti-HBc in rural areas was higher than that in urban areas, but the positive rate of Anti-HBs was lower than that in urban areas (82.60.1-14 years old), but the positive rate of Anti-HBs was lower than that in urban areas (0.0001.020).The coverage rate of Hep B and the first dose of Hep B were significantly different.The positive rate of HBs Ag in the population inoculated with Hep B was significantly lower than that in those with no or no history of inoculation.Conclusion the carrying rate of HBs Ag in Guangxi population aged 1-29 years, especially in low age children, is controlled at a lower level.Need to strengthen newborn Hep B timely vaccination and hepatitis B prevention and control of health education.
【作者单位】：广西壮族自治区疾病预防控制中心;
【分类号】：R181.3;R512.62

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