陕西省咸阳市健康人群麻疹抗体水平监测及免疫效果流行病学评价

发布时间：2018-04-19 05:37

本文选题：麻疹 + 麻疹疫苗　；参考：《中华疾病控制杂志》2017年03期

【摘要】：目的动态监测咸阳市健康人群麻疹抗体水平,并对麻疹相关疫苗的免疫效果进行流行病学评价。方法 2012-2015年,随机抽取咸阳市1 135例健康人群,采用酶联免疫吸附试验(enzyme-llinked immunosorbent assay,ELISA)检测麻疹抗体光密度(optical density,OD)值;并收集调查对象的免疫史情况,采用Logistic回归对麻疹相关疫苗进行流行病学评价。结果 2012-2015年调查对象的麻疹抗体OD值随年份略有下降趋势,在男女之间差异均无统计学意义(均有P0.05),OD值在2~3岁最高,随年龄增长有下降趋势;2012-2015年咸阳市健康人群麻疹抗体阳性率分别为:98.91%、96.81%、96.46%、85.11%;经Logistic回归分析,麻疹疫苗和麻腮风疫苗联合使用及麻疹疫苗单独使用对机体均具有明显的保护作用(麻疹疫苗+麻腮风疫苗+:OR=0.123,95%CI:0.046~0.328;麻疹疫苗+麻腮风疫苗-:OR=0.109,95%CI:0.043~0.281)。结论咸阳市健康人群中虽已建立起免疫屏障,但麻疹抗体监测及查漏补种工作仍不能松懈;麻疹疫苗是基础疫苗,对麻疹抗体的形成是必要的,麻腮风疫苗可作为强化疫苗,不能单独使用。
[Abstract]:Objective to dynamically monitor the level of measles antibody in Xianyang healthy population and to evaluate the immune effect of measles related vaccine.Methods from 2012 to 2015, 1 135 healthy people were randomly selected from Xianyang city. Enzyme linked immunosorbent assay (Elisa) was used to detect the optical density of measles antibody optical density and optical density of measles antibody, and the immune history of the subjects was collected.Logistic regression was used to evaluate the epidemiology of measles related vaccines.Results the OD value of measles antibody decreased slightly with the year 2012-2015, and there was no significant difference between men and women (P 0.05) and the OD value of measles antibody was the highest at 2 ~ 3 years old.The positive rates of measles antibody among healthy people in Xianyang city from 2012 to 2015 were respectively: 98.91%, 96.81%, 96.46%, 85.11%, respectively. The Logistic regression analysis showed that the positive rate of measles antibody in the healthy population of Xianyang city from 2012 to 2015 was 96. 81% and 85. 11% respectively.The combined use of measles vaccine and leprosy vaccine and the use of measles vaccine alone have obvious protective effects on the body (measles vaccine leprosy vaccine 0. 123 0. 123 + 95 CI: 0. 328; measles vaccine leprosy vaccine-0. 109% 95% CIW 0. 281).Conclusion although the immune barrier has been established in the healthy population of Xianyang City, the measles antibody surveillance and leak detection can not be relaxed, the measles vaccine is the basic vaccine, it is necessary for the formation of measles antibody, and the leprosy vaccine can be used as the fortified vaccine.It cannot be used alone.
【作者单位】：陕西中医药大学公共卫生学院流行病与卫生统计学教研室;西安交通大学医学部;西安医学院公共卫生系流行病与卫生统计学教研室;咸阳市疾病预防控制中心免疫规划科;
【基金】：陕西中医药大学校内基金(2015QN5)
【分类号】：R511.1;R186

【相似文献】