米非司酮顿服后不同时间对早孕蜕膜形态及类固醇受体表达的影响

发布时间：2018-05-03 14:56

  本文选题：米非司酮 + 不同时间　； 参考：《中华生殖与避孕杂志》2017年07期

【摘要】：目的探讨药物流产中缩短米非司酮用药时间的可行性。方法将80例因非意愿妊娠自愿要求终止早孕的女性随机分为4组:对照组(直接负压吸宫术)、用药后12 h组、24 h组、48 h组,3个用药组顿服米非司酮150 mg,于不同时间行负压吸引术,留取各组蜕膜组织。应用光学显微镜、透射电子显微镜观察4组蜕膜组织的形态学改变,应用免疫组织化学方法和计算机图像分析系统检测四组蜕膜组织中类固醇受体的表达。结果 3个用药组蜕膜细胞变性、坏死,间质水肿、出血,毛细血管扩张充血。对照组蜕膜组织中雌激素受体(ER)和孕激素受体(PR)阳性染色位于大部分蜕膜细胞及少数腺上皮细胞,用药后12 h组、24 h组、48 h组蛋白表达均低于对照组,差异有统计学意义(P0.05),而这3组之间无统计学差异(P0.05)。结论米非司酮用药后12 h蜕膜组织变性坏死,蛋白表达受到抑制,为临床缩短药物流产用药时间提供了一定的理论参数。
[Abstract]:Objective to study the feasibility of shortening the time of mifepristone in drug abortion. Methods Eighty women who voluntarily requested termination of early pregnancy due to unwanted pregnancy were randomly divided into four groups: control group (direct negative pressure aspiration of uterus), 12 h group, 24 h group, 48 h group, and 3 drug groups taking mifepristone 150 mg, at different time Between negative pressure suction, The decidual tissue was retained in each group. The morphologic changes of decidua tissues were observed by optical microscope and transmission electron microscope. The expression of steroid receptors in decidua tissues was detected by immunohistochemical method and computer image analysis system. Results in the three groups, decidual cell degeneration, necrosis, interstitial edema, hemorrhage, capillary dilatation and hyperemia. The positive staining of estrogen receptor (ERR) and progesterone receptor (PRP) in decidua of control group was found in most decidual cells and a few glandular epithelial cells. The difference was statistically significant (P 0.05), but there was no significant difference among the three groups (P 0.05). Conclusion the degeneration and necrosis of decidua tissue and the inhibition of protein expression at 12 h after mifepristone treatment may provide some theoretical parameters for shortening the time of drug abortion.
【作者单位】： 河北省人民医院妇产科;解放军第260医院病理科;河北省人民医院消化科;
【基金】：2017年河北省医学科学研究重点课题计划(20170254)~~
【分类号】：R169.42
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