红树莓水提取物和乙醇提取物的降血脂功能比较

发布时间：2018-05-12 19:20

本文选题：高血脂症大鼠 + 红树莓　；参考：《食品工业科技》2017年20期

【摘要】：以高脂饲料建立高血脂症大鼠模型,将红树莓水提取物、50%乙醇提取物、100%乙醇提取物按照大鼠体重以50 mg提取物/(kg·d)对高血脂症大鼠进行灌胃10周,并以等量生理盐水灌胃普通对照组和高脂对照组。通过测定灌胃前后大鼠体重、计算脏器指数和动脉粥样硬化指数(AI)的变化和大鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平、肝脏中TC和TG水平、粪便中TC和胆汁酸(TBA)含量的变化,研究红树莓提取物的降血脂功能。结果表明,与普通和高脂对照组相比,本实验建立的高血脂模型中大鼠的心脏、肾脏、胰腺和肝脏指数并无显著变化,且红树莓提取物能极显著降低高血脂大鼠的AI值(p0.01)。同时红树莓水提取物和乙醇提取物均能降低血清中TC、TG及LDL-C水平和肝脏中TC、TG水平,升高高血脂症大鼠血清HDL-C水平,促进高血脂症大鼠体内TC和TBA的排出,并抑制高血脂大鼠体重增加,且其乙醇提取物的效果比水提物更加显著。研究表明红树莓提取物具有降血脂功能,且乙醇提取物的降血脂效果优于水提取物。
[Abstract]:The rat model of hyperlipidemia was established with high fat diet. The rats with hyperlipidemia were perfused with 50% ethanol extract of red raspberry water and 100% ethanol extract at the dose of 50 mg / kg / d for 10 weeks. The control group and hyperlipidemia control group were perfused with the same amount of normal saline. The changes of body weight, organ index and atherosclerosis index (AII) were measured before and after gastric administration, and the levels of serum total cholesterol (TCN), triglyceride (TGN), high density lipoprotein cholesterol (HDL-CU), low density lipoprotein cholesterol (LDL-C) were measured. The changes of TC and TG in liver and TC and TBA in feces were studied to study the hypolipidemic function of red raspberry extract. The results showed that the indexes of heart, kidney, pancreas and liver did not change significantly in the hyperlipidemia rats compared with the normal and hyperlipidemia control groups, and the red raspberry extract could significantly decrease the AI value of hyperlipidemia rats. At the same time, red raspberry water extract and ethanol extract could decrease the levels of TCTG and LDL-C in serum and liver, increase the level of serum HDL-C in rats with hyperlipidemia, and promote the excretion of TC and TBA in hyperlipidemia rats. It also inhibited the weight gain of hyperlipidemia rats, and the effect of ethanol extract was more significant than that of water extract. The results showed that the extract of red raspberry had the function of lowering blood lipid, and the effect of ethanol extract was better than that of water extract.
【作者单位】：东北林业大学林学院;
【基金】：中央高校基本科研业务费专项基金(2572017CA05)
【分类号】：R151

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