太原市社区绝经期H型高血压患者与其雌激素水平的多重影响因素相关性分析
发布时间:2018-05-13 03:05
本文选题:H型高血压 + 雌激素 ; 参考:《山西医科大学》2013年硕士论文
【摘要】:研究目的 1.调查分析太原市杏花岭社区居民中绝经女性H型高血压患者的相关危险因素,并探讨其雌激素水平的影响因素; 2.探讨绝经女性H型高血压患者血浆中雌激素水平、Hcy与肥胖的关系。统计分析得出结论,为太原市杏花岭社区中绝经女性H型高血压患者的护理提供理论依据。 研究方法 采用随机、整群抽样方法,抽取太原市杏花岭社区常住居民2000人进行调查,对初步研究人群按照纳入、排除标准筛选得到最终研究目标人群,男性127例,女性382例。根据问诊结果将女性分为绝经组和未绝经组。问卷调查一般资料,医学体检并采集空腹肘静脉血液,测定血糖、血脂和Hcy。筛选出符合要求的女性H型高血压患者,留取其静脉血,30分钟内实验室离心处理,留取血浆后置冰箱-20℃统一编号保存(一式两份),待所有标本备齐后统一测定,采用放射免疫分析法测定筛选出的女性患者的雌二醇水平。统计分析绝经女性H型高血压患者的危险因素及与雌激素的相关性。 研究结果 1.在生化指标中,男性血浆中TC为5.14±0.91mmol/L,,女性为5.56±0.74mmol/L;男性TG为1.85±1.02mmol/L,女性为2.61±1.26mmol/L;男性Hcy为17.78±7.65umol/L,女性为23.88±5.22umol/L。女性平均TG、TC及Hcy均高于男性(P0.01);在吸烟、饮酒、高血压史等一般资料方面,男女也存在显著差异(P<0.05); 2.未绝经H型高血压组与已绝经H型高血压组相比较,年龄、腰围、高血压史、Hcy、E2,差异有统计学意义(P0.01); 3.E2与Hcy呈显著负相关,相关系数为-0.840(P<0.01); 4.绝经女性H型高血压患者血浆中Hcy的危险因素有BMI(P<0.01)、腰围(P<0.01)、E2(P<0.01)、TC(P<0.05);多因素logistic回归显示,收缩压、舒张压和高血压病程是绝经女性H型高血压的危险因素,而雌二醇为绝经女性H型高血压的保护因素; 5.影响绝经女性H型高血压患者血浆中E2水平的因素有年龄(P<0.01)、BMI(P<0.01)、LDL(P<0.05)。 结论 1.太原市杏花岭社区绝经女性雌激素水平低可能是H型高血压发病的重要影响因素,吸烟、饮酒和血糖可能不是绝经期H型高血压的危险因素; 2.Hcy水平在绝经后随女性年龄增高而升高,不随男性的年龄增高而升高; 3.肥胖可能是影响绝经女性雌激素和Hcy水平的一个健康因素。
[Abstract]:Research purpose 1. To investigate the risk factors of H type hypertension in postmenopausal women in Xinghualing community residents of Taiyuan City and to explore the influencing factors of estrogen level. 2. To investigate the relationship between plasma estrogen level and obesity in postmenopausal women with H-type hypertension. The statistical analysis provides a theoretical basis for nursing of postmenopausal female patients with H-type hypertension in Xinghualing community of Taiyuan. Research method 2000 residents of Xinghualing community in Taiyuan were selected by random and cluster sampling method. According to the inclusion and exclusion criteria, the final target population was obtained, including 127 males and 382 females. Women were divided into menopausal group and premenopausal group according to the results of inquiry. General data of questionnaire survey, medical examination and blood collection of fasting cubitus vein, blood glucose, blood lipid and Hcy. Female patients with H type hypertension were selected and their venous blood was collected for centrifugal treatment in laboratory within 30 minutes, and plasma was stored in a common number of refrigerators at 20 鈩
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