我国居民母乳和血液中多溴联苯的负荷水平研究

发布时间：2018-05-15 16:34

本文选题：多溴联苯 + 机体负荷　；参考：《南昌大学》2012年硕士论文

【摘要】：多溴联苯(PBBs)是一类溴代碳氢化合物,作为阻燃剂被广泛应用于建材、纺织、化工、电子电器等行业。这类化合物具有很强的亲脂性和稳定性,既不易溶于水也不易挥发,在使用过程中可以通过挥发、渗出等方式释放到外界环境,随着生物链在生物体内富集和放大,对人类健康和外界环境可能造成许多有害影响。国际癌症研究机构已经将十溴联苯,八溴联苯和六溴联苯列为可能的人体致癌物(IARC2B组)。2009年,六溴联苯(HBB)更是被列入斯德哥尔摩公约的持久性有机污染物新增名单中。本研究使用气相色谱-质谱仪和气相色谱-高分辨质谱仪建立了血液和母乳中PBBs的痕量分析方法,对我国居民血液和普通人群母乳中PBBs的负荷水平进行了研究,研究的主要方法、结果及结论如下： 1.采用气相色谱-质谱仪和气相色谱-高分辨质谱仪,结合稳定性同位素稀释技术及相关前处理技术,建立了血液和母乳中PBBs的痕量分析方法。建立的方法经方法学实验验证,准确、可行,适用于血液和母乳中PBBs的测定。 2.使用建立的方法对我国辽宁省普通居民血液和浙江省电子拆卸污染区居民血液中PBBs的负荷水平进行研究,结果显示在我国辽宁省普通居民血液中PBBs的负荷水平非常低。台州地区是我国典型的电子废物拆卸区之一,当地居民血液中PBBs的负荷水平会相对较高一些。但总体而言,我国居民血液中PBBs的负荷水平处于较低的水平。 3.使用建立的方法对我国普通居民母乳中PBBs的负荷水平进行研究,结果显示,我国母乳样品中PBBs存在明显的地区差别,但是城乡之间并没有显著差异,并且母乳中PBBs的负荷水平与当地的动物性膳食摄入(肉类,水产类)有显著相关。与欧美国家普通人群母乳中PBBs水平相比而言,我国母乳中PBBs含量处于一个较低的水平。
[Abstract]:Polybrominated biphenyl (PBBs) is a class of brominated hydrocarbons, which is widely used as flame retardant in building materials, textile, chemical, electronic and electrical industries. These compounds are highly lipophilic and stable, not easily soluble in water or volatile, and can be released to the outside environment by volatilization, seepage, etc., as the biological chain is enriched and amplified in the organism, There may be many harmful effects on human health and the environment. The International Agency for Research on Cancer has listed decabromobiphenyl, octabromodiphenyl and hexabromobiphenyl as potential human carcinogens (IARC2B). In 2009, HBB was added to the Stockholm Convention list of persistent organic pollutants. In this study, gas chromatography-mass spectrometer and gas chromatography-high-resolution mass spectrometer were used to establish trace analysis methods for PBBs in blood and breast milk. The loading levels of PBBs in blood and breast milk of Chinese residents and general population were studied. The main methods, results and conclusions of the study are as follows: 1. Using gas chromatography-mass spectrometer and gas chromatography-high-resolution mass spectrometer, combined with stable isotope dilution technique and related pretreatment technology, a trace analysis method of PBBs in blood and breast milk was established. The established method is proved to be accurate and feasible by methodological experiments. It is suitable for the determination of PBBs in blood and breast milk. 2. Using the established method, the load level of PBBs in the blood of the ordinary residents in Liaoning Province and the residents in the area of electronic disassembly pollution in Zhejiang Province is studied. The results show that the load level of PBBs in the blood of the ordinary residents of Liaoning Province is very low. Taizhou area is one of the typical electronic waste disassembly areas in China. The load level of PBBs in the blood of local residents will be relatively high. But overall, the load level of PBBs in the blood of Chinese residents is at a lower level. 3. By using the established method, the load level of PBBs in breast milk of ordinary residents in China was studied. The results showed that there were obvious regional differences in PBBs in breast milk samples in China, but there was no significant difference between urban and rural areas. And the load level of PBBs in breast milk was significantly correlated with the local animal dietary intake (meat, aquatic products). Compared with the level of PBBs in the general population of Europe and America, the content of PBBs in Chinese breast milk is at a low level.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R174

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