山东省健康人群流行性腮腺炎抗体水平监测

发布时间：2018-05-30 04:25

本文选题：流行性腮腺炎 + 健康人群　；参考：《中国疫苗和免疫》2017年03期

【摘要】：目的了解山东省健康人群流行性腮腺炎(腮腺炎)抗体水平,为腮腺炎免疫预防提供依据。方法 2014-2015年选取山东省10个市,按照分层随机抽样抽取0-50岁健康人群,采集血清标本,采用酶联免疫吸附试验检测腮腺炎Ig G抗体。结果共调查健康人群2 522名,血清腮腺炎抗体阳性率为86.20%、抗体几何平均浓度(Geometric mean concentration,GMC)为85.11 IU/ml。10个市人群抗体阳性率和GMC范围分别为76.52%-94.63%、54.93IU/ml-154.49IU/ml(χ~2=89.80,P0.01;F=18.56,P0.01)。人群年龄别腮腺炎抗体阳性率和GMC范围分别为67.30%(0-1岁)-94.29%(11-14岁)、64.85IU/ml(2-4岁)-104.71IU/ml(11-14岁)(χ~2=137.91,P0.01;F=3.40,P0.05);0-14岁抗体阳性率及GMC呈随年龄增加而增长的趋势。结论山东省0-50岁人群对腮腺炎已建立了较高免疫屏障;应加强1.5-2岁儿童含腮腺炎成分疫苗常规免疫的及时接种和6岁儿童的第2剂接种。
[Abstract]:Objective to investigate the antibody level of mumps (mumps) in healthy population in Shandong province and to provide evidence for immune prevention of mumps. Methods Serum samples were collected from 10 cities of Shandong Province from 2014 to 2015. The IgG antibody of mumps was detected by enzyme-linked immunosorbent assay (Elisa). Results the positive rate of mumps antibody was 86.20, and the geometric mean concentration of antibody was 85.11 IU/ml.10. The positive rate of antibody and the range of GMC were 76.52-94.633.The positive rate of mumps antibody was 76.52-94.633.The positive rate of serum mumps antibody was 86.20, and the range of GMC was 76.52-94.633.The positive rate of mumps antibody was 76.52- 94.63IUN / ml (蠂 ~ 2 / 2 ~ (89.80) P ~ (0.01) P ~ (0.01) P ~ (0.06) P ~ (0.01) respectively. The positive rate of mumps antibody and the range of GMC were 67.300-1 years old and 64.85 years old, respectively. The positive rate of anti-mumps antibody and the range of GMC were 64.85 years old or 64.85 years old, respectively. (蠂 ~ 2 137.91% P0.01F = 3.40% P 0.05 ~ 14 years old) and GMC showed an increasing trend with the increase of age. Conclusion there is a high immune barrier for mumps in the population aged 0-50 in Shandong Province, and the routine immunization of children aged 1.5 to 2 years with mumps component vaccine and the second dose vaccination of children aged 6 years should be strengthened.
【作者单位】：山东省疾病预防控制中心山东省预防控制传染病重点实验室;
【基金】：山东省科技发展计划项目(编号:2014GGH218019) 山东省泰山学者岗位支持项目
【分类号】：R186;R512.1

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