雄性生殖毒性经典遗传和表观遗传机制研究进展

发布时间：2018-06-19 22:44

本文选题：雄性 + 生殖毒性　；参考：《中国职业医学》2017年03期

【摘要】：正雄性生殖毒性主要表现为内在或外在因素对睾丸和精子的结构损伤和功能影响。随着生殖毒理学和生殖流行病学等学科的发展,近年来对雄性生殖毒性的毒性作用及其作用机制的研究日益受到重视。有研究证实,雄性生殖毒性的发生及发展既受经典遗传因素调控,又受环境因素导致的表观遗传修饰改变的影响[1-2]。因此,了解经典遗传机制和表观遗传机制对雄性生殖毒性的调控有利于阐明该类疾病的发病机制,探索相应的预防与治疗方法。本文主要针对
[Abstract]:Normal male reproductive toxicity is mainly manifested by the effects of internal or external factors on the structure and function of testis and spermatozoa. With the development of reproductive toxicology and reproductive epidemiology, more and more attention has been paid to the study of the toxic effect and mechanism of male reproductive toxicity in recent years. Some studies have confirmed that the occurrence and development of male reproductive toxicity is controlled by both classical genetic factors and the epigenetic modification caused by environmental factors [1-2]. Therefore, understanding the regulation of classical genetic mechanism and epigenetic mechanism on male reproductive toxicity is helpful to clarify the pathogenesis of this disease and to explore the corresponding prevention and treatment methods. This article mainly aims at
【作者单位】：广东药科大学公共卫生学院;中山大学公共卫生学院;广东省职业病防治院广东省职业病防治重点实验室;
【基金】：广东省自然科学基金(S2013010011816) 广东省医学科研基金(A2012068,B2014017,A2016137,A2016557) 广东省职业病防治重点实验室(2012A061400007)
【分类号】：R114

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