青年男性尿液中多环芳烃代谢物与血液肝功能指标的关联研究

发布时间：2018-08-08 19:17

【摘要】：为了解青年男性多环芳烃暴露浓度与肝功能指标之间的关联,征集郑州地区121名志愿者进行了问卷调查和血液及尿液样品采集,分析了血液中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(Alb)、球蛋白(Glo)以及白蛋白/球蛋白比值(A/G)等肝功能指标以及尿液中1-羟基芘(1-OHP)。采用相关系数、线性回归模型和逻辑斯蒂回归模型进行分析。结果发现郑州地区青年男性体内普遍存在多环芳烃暴露,尿液1-OHP浓度与AST之间存在弱的正相关关系,未在尿液1-OHP浓度与其他肝功能指标之间发现显著关联。
[Abstract]:In order to understand the correlation between polycyclic aromatic hydrocarbons (PAHs) exposure and liver function in young men, 121 volunteers in Zhengzhou were investigated and blood and urine samples were collected. Serum alanine aminotransferase (ALT),) aspartate aminotransferase (AST), 纬 -glutamyl transpeptidase) (ALP), total protein (TP), albumin (Alb), globulin (Glo) and albumin / globulin ratio (A / G) were analyzed. And 1-hydroxy pyrene (1-OHP) in urine. Correlation coefficient, linear regression model and logistic regression model were used to analyze. The results showed that polycyclic aromatic hydrocarbons (PAHs) exposure was common in young men in Zhengzhou area. There was a weak positive correlation between urinary 1-OHP concentration and AST, but no significant correlation was found between urinary 1-OHP concentration and other liver function indexes.
【作者单位】：国家烟草质量监督检验中心;
【基金】：环境化学与生态毒理学国家重点实验室开放基金(KF2014-03)资助
【分类号】：R114

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