三七-茜草宫内缓释硅橡胶棒的制备及体外释放性能的初步评价

发布时间：2018-09-10 13:56

【摘要】：制备三七-茜草宫内缓释硅橡胶棒并对其进行体外释放性能的初步评价。采用开炼机开练法进行硅橡胶的塑炼。采用正交试验法进行硅橡胶与药物的混炼工艺参数优选。采用单因素试验法进行硅橡胶棒硫化工艺参数的优选。以人参皂苷Rg1、人参皂苷Rb1、三七皂苷R1、羟基茜草素、大叶茜草素为指标,进行体外释放性能的初步评价。结果显示,硅橡胶与药物混炼的最佳工艺参数为:辊距2 mm,速比1∶1.2,前辊温55~60℃,后辊温50~55℃,塑炼时间20 min。硅橡胶棒的最佳硫化工艺参数为:温度90℃,时间60 min。体外释放度试验表明,三七-茜草宫内缓释硅橡胶棒在模拟宫腔液中的药物释放符合Higuchi方程,到90 d,人参皂苷Rg1、人参皂苷Rb1及三七皂苷R1的累积释放度为46.7%,羟基茜草素及大叶茜草素的累积释放度为51.9%。结果表明,三七-茜草宫内硅橡胶棒制备工艺合理可行,具备良好的缓释特性。
[Abstract]:Preparation of Panax Notoginseng-Rubidium Rubidiae intrauterine sustained release silicone rubber rod and its in vitro release performance preliminary evaluation. Silicone rubber molding was carried out by means of opening and scouring process. The orthogonal test was used to optimize the mixing process parameters of silicone rubber and medicine. Single factor test method was used to optimize the technological parameters of silicone rubber rod vulcanization. Ginsenoside Rg1, ginsenoside Rb1, panax notoginsenoside R1 hydroxyl alizarin and alizarin macrophylla were used as indexes to evaluate the release performance in vitro. The results show that the optimum technological parameters for mixing silicone rubber with medicine are as follows: the speed ratio of 2 mm,: 1: 1.2, the temperature of front roll 5560 鈩，

本文编号：2234639