虚拟女性体素辐射剂量学模型的建立研究

发布时间：2018-09-11 09:37

【摘要】：本工作开发了一个基于中国女性彩色解剖断层图像的体素剂量学模型(VPCF)，并利用FLUKA程序模拟计算光子的AP和PA两个照射方向下的剂量转换系数（DCCs, doseconversion coefficients）。用MATLAB R2010a和PhotoshopCS2对第三军医大学首例女性人体彩色断层图片进行了配准、分割等处理工序，最后利用Amira软件对人体模型进行了三维可视化。建立了一个体素精度为1.61mm×1.61mm×5mm，体素数量为3,958,663，包含扁桃体、卵巢、眼球、眼晶体、胃、唾液腺、牙齿、脾脏、膀胱、肝脏、心脏、胰脏、肾上腺、胆囊、乳腺、子宫、肌肉、胸腔外区、气管、食管、胸腺、甲状腺、皮肤、肾脏、脑、肺、红骨髓、大肠、小肠等35个组织或器官的中国成年女性体素模型。利用Fortran编程将VPCF在蒙特卡罗程序FLUKA中实现。在国内首次用基于光子逐点截面库EPDL97的FLUKA程序计算了光子能量在0.02MeV-10MeV范围内的20个能量点、外照射方向为AP和PA的自由空气比释动能到器官吸收剂量或有效剂量的剂量转换系数。对骨表面、红骨髓、皮肤等特殊器官，选择了较为合适的剂量计算方法。对模拟计算数据进行了充分的分析工作。较系统地评价了VPCF模型与ICRP女性参考人体素模型、数学模型和CRAM的光子外照射剂量转换系数的差异，，并给出了合理的解释。有效剂量转换系数的差别不像单个器官的那么大。在光子能区（20keV-80keV），AP方向照射，VPCF模型与Regina模型的有效剂量DCCs基本相等，但对PA方向照射，VPCF模型有效剂量DCCs比Regina模型的大12.4%。在能区（80keV-10MeV），AP、PA方向照射，总体上VPCF模型有效剂量的DCCs比Regina模型大0.85%。
[Abstract]:In this work, a volumetric dosimetry model (VPCF),) based on Chinese female color anatomical sectional images was developed, and the dosimetric conversion coefficient (DCCs, doseconversion coefficients).) was simulated by FLUKA program in the direction of AP and PA of photons. MATLAB R2010a and PhotoshopCS2 were used to deal with the first female human body color tomographic images in the third military Medical University. Finally, the 3D visualization of the human body model was carried out by using Amira software. An individual hormone with a precision of 1.61mm 脳 1.61mm 脳 5 mm and a volume of 3 ~ 958 ~ 663 mm was established. It contains tonsils, ovaries, eyeball, eye lens, stomach, salivary gland, teeth, spleen, bladder, liver, heart, pancreas, adrenal gland, gallbladder, mammary gland, uterus, muscle. 35 Chinese adult female voxel models including extrathoracic area trachea esophagus thymus thyroid skin kidney brain lung red bone marrow large intestine small intestine and so on. VPCF is realized in Monte Carlo program FLUKA by Fortran programming. For the first time in China, a FLUKA program based on the photon point-by-point cross-section library (EPDL97) is used to calculate the dose conversion coefficients of the free air specific kinetic energy from the photon energy in the range of 0.02MeV-10MeV to the absorbed dose or effective dose of the organ with the directions of AP and PA. A more suitable dose calculation method was selected for special organs such as bone surface, red bone marrow, skin and so on. Full analysis of the simulated data is carried out. The difference of dose conversion coefficient between VPCF model and ICRP female reference anthropomorphine model, mathematical model and CRAM is systematically evaluated, and a reasonable explanation is given. The difference in effective dose conversion coefficients is not as large as that of individual organs. The effective dose of VPCF model irradiated in the photon energy region (20keV-80keV) in the AP direction is basically equal to that in the Regina model, but the effective dose DCCs in the PA direction irradiation model is 12.4% larger than that in the Regina model. On the whole, the effective dose of DCCs in VPCF model was 0.85 larger than that in Regina model.
【学位授予单位】：哈尔滨工程大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R144

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