化学品甲状腺干扰效应的计算毒理学研究进展

发布时间：2018-11-13 17:35

【摘要】：人工合成化学品引发的内分泌干扰效应(如甲状腺干扰效应)引起了全世界的广泛关注.在当前全球市场使用的14万多种人工合成化学品中,仅部分化学品具有内分泌干扰效应信息.由于整体动物实验成本高、耗时长,难以对所有潜在内分泌干扰物(EDCs)进行逐个筛查.因此,需要发展化学品环境内分泌干扰效应的计算毒理学方法,用于筛查潜在EDCs及辅助筛选环境优先污染物.本文总结了化学品甲状腺干扰效应的计算毒理学研究进展,主要包括甲状腺干扰物与甲状腺素受体、甲状腺素运载蛋白、甲状腺素磺酸基转移酶相互作用的分子机制及相应干扰效应的定量构效关系模型研究进展.对基于计算毒理学方法开展甲状腺干扰效应方面的研究进行了展望.
[Abstract]:Endocrine disruptions induced by synthetic chemicals, such as thyroid disruptions, have attracted worldwide attention. Of the more than 140000 synthetic chemicals currently used in the global market, only some chemicals have endocrine disrupting effect information. It is difficult to screen all potential endocrine disruptors (EDCs) one by one because of the high cost and time consuming of the whole animal experiment. Therefore, it is necessary to develop a toxicological method to calculate the environmental endocrine disrupting effect of chemicals for screening potential EDCs and auxiliary screening of environmental priority pollutants. In this paper, the recent advances in the toxicological study of the thyroid interference effects of chemicals were reviewed, including thyroid disruptors and thyroxine receptors, thyroxine transport proteins. Advances in the molecular mechanism of thyroxine sulphotransferase interaction and the quantitative structure-activity relationship model of the corresponding interference effects. The research on thyroid interference effect based on computational toxicology is prospected.
【作者单位】：大连理工大学环境学院工业生态与环境工程教育部重点实验室;环境保护部南京环境科学研究所;中国科学院烟台海岸带研究所;
【基金】：国家自然科学基金(21325729,21137001)资助
【分类号】：R114;TQ086.51

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