2007-2015年中山市疑似预防接种异常反应监测分析

发布时间：2018-11-27 07:40

【摘要】：目的对2007-2015年中山市疑似预防接种异常反应(Adverse Event Following Immunization,AEFI)监测数据进行分析,评价AEFI监测系统运转情况和预防接种的安全性。方法收集2007-2015年发生AEFI个案和疫苗接种数据,采用描述性方法进行流行病学分析。结果 2007-2015年中山市AEFI报告县覆盖率100%,发现个案48 h内报告97.23%,48 h内调查98.45%,调查后3 d内报告100%,项目填写完整率100%和分类率98.76%。AEFI发生率为26.83/10万;男女性别比为1.54∶1;1岁占病例数40.02%;1岁各月龄均有病例发生。AEFI分类以一般反应为主,占82.37%;临床诊断以发热/红肿/硬结为主,占80.77%;94.17%的AEFI发生在接种后3 d内。AEFI发生率高的前5种疫苗分别为7价肺炎疫苗、23价肺炎疫苗、DTa P-IPV/Hib联合疫苗、DTa P-Hib联合疫苗、百白破疫苗。结论 2007-2015年中山市AEFI监测系统运转良好,监测数据质量高,基本能够反映出预防接种安全性的真实水平。
[Abstract]:Objective to analyze the monitoring data of suspected abnormal vaccination reaction (Adverse Event Following Immunization,AEFI) in Zhongshan City from 2007 to 2015, and to evaluate the operation of AEFI monitoring system and the safety of vaccination. Methods AEFI cases and vaccination data were collected from 2007 to 2015 and epidemiological analysis was carried out by descriptive method. Results from 2007 to 2015, the coverage rate of AEFI reporting county in Zhongshan City was 100. The report of the case within 48 hours and within 48 hours was 98.455.The report was reported within 3 days after investigation. The complete completion rate and the classification rate of 98.76%.AEFI were 100% and 26.83 / 100 thousand respectively. The sex ratio of male to female was 1.54: 1 (40.02%). There were cases in all months of age. The AEFI classification was based on general reaction (82.37%) and fever / redness / sclerosis (80.77%) in clinical diagnosis. 94.17% of AEFI occurred within 3 days after inoculation. The first five vaccines with high incidence of AEFI were 7 valent pneumonia vaccine, 23 valent pneumonia vaccine, DTa P-IPV/Hib combined vaccine, DTa P-Hib combined vaccine and DPT vaccine. Conclusion the AEFI monitoring system in Zhongshan City from 2007 to 2015 runs well and the quality of monitoring data is high, which can basically reflect the true level of vaccination safety.
【作者单位】：中山市疾病预防控制中心;
【分类号】：R186

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