两种增加骨密度功能保健食品的功效研究

发布时间：2018-12-19 12:57

【摘要】：目的对2种以碳酸钙、氨基酸葡萄糖、硫酸软骨素为主要组分但不同配比的增加骨密度类保健食品的功效进行验证,从配方角度进行分析评价。方法采用相当于人体推荐剂量的5、10、30倍浓度分别将氨糖软骨素片(0.33、0.67、2.00 g/kg)及骨密度强化胶囊(0.25、0.5、1.5 g/kg)掺入饲料给予大鼠90 d,同时分别设置与30倍剂量组钙含量相同的碳酸钙对照组。测定大鼠体质量、股骨质量、股骨密度及股骨钙含量等指标,对比配方及结果进行分析和讨论。结果股骨质量,增加骨密度胶囊10、30倍剂量组与碳酸钙组比较差异无统计学意义(P0.05)。氨糖软骨素片30倍剂量组与碳酸钙组比较差异无统计学意义(P0.05);股骨中点骨密度,增加骨密度胶囊30倍剂量组与碳酸钙组比较差异无统计学意义(P0.05)。氨糖软骨素片30倍剂量组与碳酸钙组比较差异无统计学意义(P0.05);股骨远心端骨密度,增加骨密度胶囊10、30倍剂量组与相应碳酸钙组比较差异无统计学意义(P0.05)。氨糖软骨素片10、30倍剂量组与相应碳酸钙组比较差异无统计学意义(P0.05);股骨钙含量,增加骨密度胶囊30倍剂量组与相应碳酸钙组比较差异无统计学意义(P0.05)。氨糖软骨素片10倍、30倍剂量组与30倍碳酸钙组比较差异无统计学意义(P0.05);饲料钙含量,低钙饲料实测钙含量为1.2 mg/g。结论2种配方的保健食品均具有增加骨密度功效,氨糖软骨素片较增加骨密度胶囊配方更合理。
[Abstract]:Objective to verify the efficacy of two kinds of health foods with calcium carbonate, amino acid glucose and chondroitin sulfate as main components but with different proportions to increase bone mineral density. Methods the rats were fed with amitosamine chondroitin tablets (0.33 g/kg) and bone mineral density strengthening capsule (0.25 g/kg) for 90 days with a concentration of 10 ~ 10 ~ 30 times the recommended dose of 5 chondroitin (0.33 ~ 0.67) and BMD (0.25 ~ 0.55 ~ (1.5) g/kg) respectively. At the same time, calcium carbonate control group with the same calcium content as 30 times dose group was set up respectively. Body mass, femoral bone mineral density and femur calcium content were measured, and the formula and results were analyzed and discussed. Results there was no significant difference in femur quality between 10 and 30 times of BMD capsule group and calcium carbonate group (P0.05). There was no significant difference between the 30 times dosage group and the calcium carbonate group (P0.05); the bone mineral density at the middle point of femur and the increase of bone mineral density capsule 30 times dose group had no statistical significance compared with the calcium carbonate group (P0.05). There was no significant difference between the 30 times dosage group and the calcium carbonate group (P0.05), while there was no significant difference between the 30 times dose group and the corresponding calcium carbonate group (P0.05). There was no significant difference between the 10 ~ 30 times dosage group and the corresponding calcium carbonate group (P0.05); there was no significant difference between the 30 times dose group and the corresponding calcium carbonate group (P0.05). There was no significant difference between the 10 times, 30 times dosage groups and the 30 times calcium carbonate group (P0.05); the calcium content in feed was 1.2 mg/g., the measured calcium content in low calcium diet was 1.2 mg/g.. Conclusion the two formulations of health food have the effect of increasing bone mineral density, and the formula of amitose chondroitin tablet is more reasonable than that of increasing bone mineral density capsule.
【作者单位】：中国食品药品检定研究院;
【分类号】：TS218;R151

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