人血中有机卤代化合物的水平及其与甲状腺指标的相关性研究
发布时间：2019-01-03 16:23
【摘要】：持久性有机物污染物(Persistent Organic Pollutants, POPs)所引起的环境问题日益严重,对人类和生态环境都具有很大的潜在威胁,受到各国各界的重视。目前十溴联苯醚在人血中的含量正逐年增高,而且其在环境中及人体中还可能发生代谢或降解作用,生成低溴代的或羟基化的PBDE,其对人体健康的影响不容忽视。而PCB和OCPs虽然已禁止生产和使用,但由于其持久性、难降解、脂溶性及生物富集作用,其在人体中仍将存在一段时间。新型阻燃剂DP,其使用其实已有四十多年的历史,但是近几年才开始引起人们的注意,人血中DP水平数据及毒理学数据缺乏,健康影响不明确。 本文建立了凝胶渗透色谱(GPC)去脂、气相色谱-负化学电离源-质谱(GC-NCI-MS)法测定PBDEs、PCBs、DP及OCPs的方法。研究采集并测定了潍坊及南宁各40个人血清样本中上述化合物浓度。本研究发现潍坊地区Σ4PBDEs (BDE-100、99、153及183)浓度范围在3.4-62ng/g脂重,平均浓度为11ng/g脂重,中值为6.4ng/g脂重,BDE-209范围从ND-100000ng/g脂重,均值和中值分别为1200和440ng/g脂重。而Σ2PCBs (BDE-180、170)浓度范围在ND-14ng/g脂重,平均浓度为3.2ng/g脂重,中值为2.5ng/g脂重。∑DP浓度范围在ND-36ng/g脂重,平均浓度为3.6ng/g脂重,中值为1.8ng/g脂重,fanti值从0.27到0.93不等,均值为0.65。HCB及ΣDDT浓度范围分别为57-420ng/g脂重和49-38000ng/g脂重,平均浓度分别为130ng/g脂重和3100ng/g脂重,中值分别为110ng/g脂重和1200ng/g脂重。 而南宁地区Σ4PBDEs在2.0-14ng/g脂重,平均浓度为5.0ng/g脂重,中值为4.80ng/g脂重。BDE-209范围从ND-6300ng/g脂重,均值和中值分别为720和270ng/g脂重。∑2PCB在ND-4.9ng/g脂重,平均浓度为1.4ng/g脂重,中值为1.3ng/g脂重。ΣDP浓度范围在ND-20ng/g脂重,平均浓度为3.3ng/g脂重,中值为1.8ng/g脂重,fanti值从0.35到0.95不等,均值为0.71。HCB及ΣDDT浓度范围为26-240ng/g脂重和ND-11000ng/g脂重,平均浓度分别为63ng/g脂重和1400ng/g脂重,中值分别为53ng/g脂重和760ng/g脂重。 本研究中检出的PBDEs. PCBs及OCPs均显示出潍坊高于南宁的趋势,统计学结果也显示两地BDE-100、99、153,PCB-180、170及HCB的水平存在显著性差异。而两地DP水平相当,统计学上也无显著性差异,而且两地fanti值较高,说明两地DP组成以anti-DP为主。 本研究同时对潍坊及南宁人血清样品5项甲状腺指标做了检测,80个样本总异常率达到了50%。对4类有机卤代化合物与甲状腺功能指标的相关关系,多元线性回归分析结果表明山东人群fT3水平可能受BDE-183及p-HCH的影响,而且前者占主导影响；而南宁人群fT3水平则可能受PCB-180及PCB-170的影响,并以PCB-170为主。虽然本研究中统计学并未发现更多4类有机卤代化合物与甲状腺功能指标的相关性,但是两地甲状腺指标异常率之高不容忽视,更多研究包括动物毒性实验应该深入进行,以评价其健康影响。
[Abstract]:The environmental problems caused by persistent organic pollutants (Persistent Organic Pollutants, POPs) are becoming more and more serious, which have a great potential threat to human and ecological environment. At present, the content of decabromodiphenyl ether in human blood is increasing year by year, and it may be metabolized or degraded in the environment and human body. The effect of decabromodiphenyl ether on human health can not be ignored. Although PCB and OCPs have been banned from production and use, they will still exist in human body for some time due to their persistence, refractory degradation, liposolubility and bioconcentration. The new flame retardant DP, has been used for more than 40 years, but in recent years, it has attracted people's attention. The data of DP level and toxicology in human blood are lacking, and the health effects are not clear. A method for the determination of PBDEs,PCBs,DP and OCPs by gel permeation chromatography (GPC) and gas chromatography-negative chemical ionization source-mass spectrometry (GC-NCI-MS) was established. The concentrations of these compounds in 40 serum samples from Weifang and Nanning were determined. In this study, the concentrations of 危 4PBDEs (BDE-100,99153 and 183) in Weifang area were found to be in the range of 3.4-62ng/g lipid weight, the average concentration was 11ng/g lipid weight, the median was 6.4ng/g lipid weight, and the BDE-209 range was ND-100000ng/g lipid weight. The mean value and median value were 1200 and 440ng/g respectively. While 危 2PCBs (BDE-180170) concentration was in the range of ND-14ng/g lipid weight, the average concentration was 3.2ng/g lipid weight, the median was 2.5ng/g lipid weight, 鈭，
本文编号：2399610
[Abstract]:The environmental problems caused by persistent organic pollutants (Persistent Organic Pollutants, POPs) are becoming more and more serious, which have a great potential threat to human and ecological environment. At present, the content of decabromodiphenyl ether in human blood is increasing year by year, and it may be metabolized or degraded in the environment and human body. The effect of decabromodiphenyl ether on human health can not be ignored. Although PCB and OCPs have been banned from production and use, they will still exist in human body for some time due to their persistence, refractory degradation, liposolubility and bioconcentration. The new flame retardant DP, has been used for more than 40 years, but in recent years, it has attracted people's attention. The data of DP level and toxicology in human blood are lacking, and the health effects are not clear. A method for the determination of PBDEs,PCBs,DP and OCPs by gel permeation chromatography (GPC) and gas chromatography-negative chemical ionization source-mass spectrometry (GC-NCI-MS) was established. The concentrations of these compounds in 40 serum samples from Weifang and Nanning were determined. In this study, the concentrations of 危 4PBDEs (BDE-100,99153 and 183) in Weifang area were found to be in the range of 3.4-62ng/g lipid weight, the average concentration was 11ng/g lipid weight, the median was 6.4ng/g lipid weight, and the BDE-209 range was ND-100000ng/g lipid weight. The mean value and median value were 1200 and 440ng/g respectively. While 危 2PCBs (BDE-180170) concentration was in the range of ND-14ng/g lipid weight, the average concentration was 3.2ng/g lipid weight, the median was 2.5ng/g lipid weight, 鈭，
本文编号：2399610
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