肥胖模型大鼠铁代谢和铁营养状态指标的检测及其意义

发布时间：2019-01-06 14:02

【摘要】：目的:研究肥胖大鼠铁代谢和铁营养状态,为防治肥胖性铁营养不良提供理论依据。方法:将27只雄性Wistar大鼠随机分为对照组(n=10)和肥胖组(n=17),分别喂养普通饲料和高脂饲料,12周后眼球取血处死。全血测定血红蛋白、红细胞数、血细胞压积;血清测定血清铁、总铁蛋白结合力、血清转铁蛋白饱和度、铁调素、转铁蛋白及铁蛋白。结果:与对照组比较,肥胖组大鼠红细胞总数、红细胞压积值升高,血红蛋白含量降低,其中红细胞总数与对照组比较差异有统计学意义(P0.05)。肥胖组大鼠血清铁、铁饱和度降低,血清总铁结合力升高,其中血清铁、铁饱和度水平与对照组比较差异有统计学意义(P0.05);肥胖组大鼠铁蛋白、铁调素、转铁蛋白降低,其中铁蛋白、铁调素水平与对照组比较差异有统计学意义(P0.05)。结论:肥胖会导致铁营养不良,引起铁代谢指标的改变。肥胖者应注意补充铁的摄入。
[Abstract]:Objective: to study iron metabolism and iron nutrition status in obese rats and to provide theoretical basis for prevention and treatment of obese iron malnutrition. Methods: 27 male Wistar rats were randomly divided into two groups: control group (n = 10) and obese group (n = 17). Hemoglobin, erythrocyte count, hematocrit, serum iron, total ferritin binding ability, serum transferrin saturation, iron modulin, transferrin and ferritin were measured in whole blood. Results: compared with the control group, the total erythrocyte count, hematocrit value and hemoglobin content in the obese group were increased, and the difference between the total erythrocyte count and the control group was statistically significant (P0.05). The serum iron and iron saturation decreased and the serum total iron binding capacity increased in obese rats. The serum iron and iron saturation levels were significantly higher than those in the control group (P0.05). The levels of ferritin, iron modulin and transferrin in obese group were significantly lower than those in control group (P0.05). Conclusion: obesity may lead to iron malnutrition and change of iron metabolism. Obese people should pay attention to iron intake.
【作者单位】：吉林大学公共卫生学院营养与食品卫生学教研室;
【基金】：吉林省卫生厅科研基金资助课题(2011Z056)
【分类号】：R-332

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