铝电解职业人群认知功能和基因甲基化关系研究
发布时间：2019-01-10 15:30
【摘要】：目的探讨铝电解职业人群认知功能减退和周围血全基因组甲基化改变之间的关系。方法采用横断面调查方法,以366名从事铝电解作业10年以上的工人为铝接触组,以102名面粉厂工人为对照组。2组人群均采用简易精神状态量表(MMSE)评价认知功能,采集周围血检测血清铝水平和全基因组甲基化率。铝接触组人群根据是否检出轻度认知功能障碍(MCI)分为MCI和非MCI亚组。结果与对照组比较,铝接触组人群血清铝水平较高[中位数(M):48.99 vs 29.17μg/L,P0.01],MMSE总分较低[(27.78±1.38)vs(29.10±1.77)分,P0.01],MCI检出率较高(11.75%vs 2.94%,P0.01),全基因组甲基化率较低[M:15.05%vs 17.01%,P0.01]。铝接触组人群MMSE总分和全基因组甲基化率均随血清铝水平增加而下降(P0.05)。铝接触组人群MCI亚组全基因组甲基化率低于非MCI亚组[M:15.53%vs 17.54%,P0.05]。多元线性逐步回归分析结果显示,铝电解职业人群MMSE总分与血清铝水平呈负相关(P0.05),与全基因组甲基化水平呈正相关(P0.01)。结论长期接触铝可以导致职业人群MCI,其认知水平和铝接触水平及周围血全基因组甲基化水平均有关联。
[Abstract]:Objective to investigate the relationship between cognitive impairment and genomic methylation of peripheral blood in aluminum electrolysis workers. Methods A cross-sectional survey was conducted. 366 workers who had been engaged in aluminum electrolysis for more than 10 years were selected as the aluminum exposure group and 102 flour mill workers as the control group. The cognitive function was evaluated by simple mental state scale (MMSE) in both groups. Peripheral blood samples were collected to detect serum aluminum level and genomic methylation rate. Aluminum exposure group was divided into MCI subgroup and non-MCI subgroup according to whether mild cognitive impairment (MCI) was detected. Results compared with the control group, the serum Al level in the aluminum exposure group was higher [median (M): 48.99 vs 29.17 渭 g / L P0.01], and the total MMSE score was lower [(27.78 卤1.38) vs (29.10 卤1.77), P 0.01]. The detection rate of MCI was higher (11.75%vs 2.94) and the whole genome methylation rate was lower [M:15.05%vs 17.01]. The total MMSE score and total genomic methylation rate of aluminum exposure group decreased with the increase of serum aluminum level (P0.05). The total genomic methylation rate of MCI subgroup in aluminum exposure group was lower than that in non MCI subgroup [M:15.53%vs 17.54% P0.05]. Multiple linear stepwise regression analysis showed that the total score of MMSE in aluminum electrolysis workers was negatively correlated with serum aluminum level (P0.05) and positively correlated with the whole genome methylation level (P0.01). Conclusion Long-term exposure to aluminum can lead to the association of MCI, cognitive level with aluminum exposure level and the whole genome methylation level of peripheral blood.
【作者单位】： 山西医科大学第一临床医学院老年病科;山西医科大学公共卫生学院劳动卫生教研室;
【基金】：国家自然科学基金重点项目(81430078)
【分类号】：R135
[Abstract]:Objective to investigate the relationship between cognitive impairment and genomic methylation of peripheral blood in aluminum electrolysis workers. Methods A cross-sectional survey was conducted. 366 workers who had been engaged in aluminum electrolysis for more than 10 years were selected as the aluminum exposure group and 102 flour mill workers as the control group. The cognitive function was evaluated by simple mental state scale (MMSE) in both groups. Peripheral blood samples were collected to detect serum aluminum level and genomic methylation rate. Aluminum exposure group was divided into MCI subgroup and non-MCI subgroup according to whether mild cognitive impairment (MCI) was detected. Results compared with the control group, the serum Al level in the aluminum exposure group was higher [median (M): 48.99 vs 29.17 渭 g / L P0.01], and the total MMSE score was lower [(27.78 卤1.38) vs (29.10 卤1.77), P 0.01]. The detection rate of MCI was higher (11.75%vs 2.94) and the whole genome methylation rate was lower [M:15.05%vs 17.01]. The total MMSE score and total genomic methylation rate of aluminum exposure group decreased with the increase of serum aluminum level (P0.05). The total genomic methylation rate of MCI subgroup in aluminum exposure group was lower than that in non MCI subgroup [M:15.53%vs 17.54% P0.05]. Multiple linear stepwise regression analysis showed that the total score of MMSE in aluminum electrolysis workers was negatively correlated with serum aluminum level (P0.05) and positively correlated with the whole genome methylation level (P0.01). Conclusion Long-term exposure to aluminum can lead to the association of MCI, cognitive level with aluminum exposure level and the whole genome methylation level of peripheral blood.
【作者单位】： 山西医科大学第一临床医学院老年病科;山西医科大学公共卫生学院劳动卫生教研室;
【基金】：国家自然科学基金重点项目(81430078)
【分类号】：R135
【相似文献】
相关期刊论文 前2条
1 刘永泉，，陈一新，肖远东，孟`伔
本文编号：2406485
本文链接：https://www.wllwen.com/yixuelunwen/yufangyixuelunwen/2406485.html
