鱿鱼卵磷脂对东莨菪碱痴呆小鼠学习记忆功能的影响

发布时间：2019-02-13 11:31

【摘要】：本文比较研究了鱿鱼卵磷脂和蛋黄磷脂对老年痴呆小鼠学习记忆能力的影响。雄性BALB/c小鼠分为正常对照、模型、鱿鱼卵磷组(SL)和蛋黄磷脂组(EL),喂养1周后,腹腔注射东莨菪碱造模并进行行为学测试。测定脑皮层、白质、海马中乙酰胆碱酯酶(Tch E)、超氧化物歧化酶(SOD)、单胺氧化酶(MAO)活力和脑内丙二醛(MDA)含量。结果显示,SL组水迷宫潜伏期显著降低,而穿越平台次数和目标象限停留时间显著提高,行为学改善效果优于EL组。SL能显著降低脑内各组织Tch E活力、MDA水平和白质中MAO活力,显著提高脑皮层、海马和白质中SOD活力,且作用效果优于EL。综上,鱿鱼卵磷脂通过影响中枢胆碱能神经系统和脑内抗氧化系统,改善了东莨菪碱所致痴呆小鼠学习记忆能力。
[Abstract]:The effects of squid lecithin and egg yolk phospholipid on learning and memory ability of senile dementia mice were studied. Male BALB/c mice were divided into normal control model squid egg phosphorus group (SL) and egg yolk phospholipid group (EL),) for 1 week. The activity of acetylcholinesterase (Tch E),) superoxide dismutase (SOD),) monoamine oxidase (SOD),) (MAO) and the content of malondialdehyde (MDA) in cerebral cortex white matter and hippocampus were measured. The results showed that the latency of water labyrinth decreased significantly in SL group, but the times of crossing platform and the residence time of target quadrant increased significantly. The effect of behavioral improvement was better than that of EL group. SL could significantly reduce the activity of Tch E in brain tissue. The level of MDA and the activity of MAO in white matter significantly increased the activity of SOD in cortex, hippocampus and white matter, and the effect was better than that of EL.. In conclusion, squid lecithin can improve the learning and memory ability of scopolamine induced dementia mice by affecting the central cholinergic nervous system and brain antioxidant system.
【作者单位】：中国海洋大学食品科学与工程学院;青岛市市立医院检验科;
【基金】：国家科技支撑计划项目(2012BAD33B07) 山东省自主创新专项(2012CX80201) 教育部“新世纪优秀人才支持计划”(NCET-04-0642)
【分类号】：R151;TS201.4

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