开菲尔对高脂金黄地鼠肠道菌群的调节作用研究

发布时间：2019-02-16 08:03

【摘要】：利用高脂金黄地鼠模型研究开菲尔对肠道菌群的调节作用。体质量、肝脏质量、附睾脂肪质量、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)测定结果表明,开菲尔能够有效控制高脂饲料引起的体质量、附睾脂肪质量增加以及LDL-C/HDL-C比值的升高(开菲尔实验组体质量、附睾脂肪质量、LDL-C/HDL-C比值分别为149.8 g、4.0 g、0.7,显著低于高脂饲料对照组的172.1 g、5.5 g、1.1)。高通量测序分析结果显示,开菲尔能够显著下调拟杆菌门、脱铁杆菌门、变形菌门和TM7菌门组成比例和上调厚壁菌门、柔膜菌门和疣微菌门比例;能够上调Akkermansia muciniphila的组成比例,并下调Alistipes indistinctus和Mucispirillum schaedleri的组成比例。因此,推断开菲尔能够调节高脂饲料引起的肠道菌群失调,抑制体质量增加和降低血脂指标。
[Abstract]:The effect of Kefir on intestinal flora was studied by using high fat golden hamster model. Body mass, liver mass, epididymal fat mass, total cholesterol (TC), triglyceride, (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were measured. Kefir could effectively control the body mass, the increase of epididymal fat mass and the increase of LDL-C/HDL-C ratio caused by high fat diet (the body weight, epididymal fat mass and LDL-C/HDL-C ratio of Keifel experimental group were 149.8 g, respectively). It was significantly lower than that of high fat diet group (172.1 g / L, 172.1 g / g). The results of high-throughput sequencing showed that Kefir could significantly down-regulate the proportion of Bacteroides, Ferriodactylum, Proteus and TM7 phylum and upregulate the proportion of phylum pachymatidis, phylum flexurus and Microphylum verrucosa. Can increase the composition of Akkermansia muciniphila, and down-regulate the composition of Alistipes indistinctus and Mucispirillum schaedleri. Therefore, it is inferred that Keifel can regulate intestinal microflora disorder, inhibit the increase of body mass and decrease the index of blood lipids caused by high fat feed.
【作者单位】：中国疾病预防控制中心营养与健康所;国家卫生计生委微量元素营养重点实验室;中粮营养健康研究院有限公司;
【基金】：科技部-国家重点研发计划课题(2016YFD0400602)
【分类号】：R151

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